Effects of Immunotherapy on T-lymphocyte and Cytokine Composition

Effects of Immunotherapy on T-lymphocyte and Cytokine Composition

Amaç, materiyal ve metod: Allerjik bireylerde immunoterapinin (İT) serum interferon-gama (İFN-g) düzeyinde ve T-lenfosit subgruplarına olan etkisini araştırmak amacıyla 40 allerjik rinitli hasta ile 10 sağlıklı bireylerden beş çalışma grubu oluşturuldu. I.                    Grup: İT öncesi İFN-g ölçülen 10 kişi II.                 Grup: İT bitiminde İFN-g düzeyleri ölçülen 10 kişi III.               Grup: İT bitiminden 3. kontrol yılında İFN-g düzeyleri ölçülen 10 kişi IV.              Grup: İT öncesi ve sonrası T4,T8 lenfosit düzeyleri ölçülen 10 kişi V.                Grup: kontrol grubu İFN-g düzeyleri ölçülen 10 kişi Sonuç: I.grupta, İT öncesi serum İFN-g düzeyi bakılarak kontrol grubu ile karşılaştırıldı. İkisi arasında anlamlı bir fark bulunmadı. II.grupta ise İT sonrası İFN-g düzeyine bakıldı. İT sonrası İFN-g düzeyi, I. grup ve kontrol grubu düzeyleri ile karşılaştırılarak İFN-g seviyesinde belirgin yükselme görüldü. Aynı şekilde III. grupta İT sonrası 3. kontrol yılında bakılan serum İFN-g düzeyi, I. grup ve kontrol grubu düzeyleri ile karşılaştırılarak anlamlı miktarda yüksek bulundu. IV. grupta ise İT öncesi ve sonrası periferik kandaki T4, T8 ve T4/T8miktarlarına bakıldı. Tartışma: İT sonrasında T4 düzeyinde azalma, T8 düzeyinde artma ve T4/T8 oranında düşme görüldü.  

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