Meral GÜNHAN, Cemil NURAL, Mahmure Ayşe TAYMAN, Ceylan BAL

Periodontitis Hastalarında Dinamik Tiyol/Disülfid HomeostazınınDeğerlendirilmesi

Amaç: Tiyoller, sülfhidril grubuna sahip antioksidan organik bileşiklerdir. Dinamik tiyol/disülfid homeostazı, oksidatif stresin bir belirteci olarak kabul edilmektedir. Bu çalışmanın amacı, evre III-derece C jeneralize periodontitisli hastalarda tiyol ve disülfid düzeylerini belirlemek ve klinik periodontal parametrelerle [sondalamada kanama (SK), klinik ataçman kaybı (KAK), sondalamada cep derinliği (CD)] biyokimyasal parametreler arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntemler: Çalışmaya 48 kişi dahil edildi (Kontrol n+23, periodontitis n=25). Grupların SK, KAK ve CD değerleri cerrahi olmayan periodontal tedaviden önce ve sonra kaydedildi. Tiyol disülfid homeostazı otomatik ve yeni bir spektrofotometrik yöntemle değerlendirildi. Disülfid/toplam tiyol, disülfür/doğal tiyol ve doğal tiyol/toplam tiyol yüzdeleri hesaplandı. Bulgular: Periodontitis grubunun klinik periodontal parametreleri tedaviden önce yüksekti (p

Evaluation of Dynamic Thiol/Disulphide Homeostasis in Patients with Periodontitis

Objective: Thiols are antioxidant organic compounds with sulfhydryl group. Dynamic thiol/disulphide homeostasis is considered a marker of oxidative stress. This study aimed to determine disulphide and thiol levels in patients with generalised stage III grade C periodontitis and to investigate the relationship between biochemical and clinical periodontal parameters, namely, bleeding on probing (BOP), clinical attachment level (CAL) and probing pocket depth (PPD). Materials and Methods: Forty-eight individuals participated in the study (control, n=23; periodontitis, n=25). BOP, CAL and PPD values of the groups were recorded before and after non-surgical periodontal treatment. Thiol disulphide homeostasis was assessed by an automatic and a new spectrophotometric method. Percentages of disulphide/total thiol, disulphide/native thiol and native thiol/total thiol were calculated. Results: The clinical periodontal parameters of the periodontitis group were higher (p

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