Özgül PAŞAOĞLU, Funda CANAZ, Evrim ÇİFTÇİ, Ercüment PAŞAOĞLU

MEMENİN İNVAZİV MİKROPAPİLLER KARSİNOMU: BİR OLGU SUNUMU

Memenin invaziv mikropapiller karsinomu invaziv duktal karsinomun nadir bir varyantıdır. Bu tümörün klinik özellikleri yüksek oranda lenf nodu metastazı, vasküler invazyon ve kötü prognozdur. 70 yaşında bayan hasta sağ memesinde ilk olarak ultrasonografik incelemede tespit edilen kitle ile başvurmuştur. Fizik incelemede palpable kitle bulunmamıştır. Eksizyonel biyopsi yapılan hastaya, invaziv mikropapiller karsinom tanısı verilmiştir. Daha sonra hastaya sağ modifiye radikal mastektomi ve aksiller diseksiyon yapılmıştır. Histolojik olarak, tümör ince fibrokollajenöz stroma ile ayrılan, boş laküner alanlar içerisinde psödopapiller yapılardan oluşmaktaydı. Psödopapiller yapılarda fibrovasküler korlar gözlenmemiştir. Tümöral hücrelerde östrojen ve progesteron reseptör pozitif, C-erb-B2 ve Wilms' tümör- 1 (WT-1) negatiftir. Ca 125 ile tümöral hücrelerde membranöz ve sitoplazmik boyanma izlenmiştir. Bu olguda invaziv duktal karsinomun nadir bir alt tipi sunularak, histopatolojik ve immünohistokimyasal bulguları tartışılmıştır

Anahtar Kelimeler:

Meme, invaziv mikropapiller karsinom, immünohistokimyasal inceleme

Invasive Micropapillary Carcinoma of the Breast: A Case Report

Invasive micropapillary carcinoma of the breast is a rare subtype of invasive ductal carcinoma. It's clinical characteristics include a high rate of lymph node metastasis, vascular invasion, and poor prognosis. A 70-year-old postmenopausal woman presented with a lesion on the right breast that had been first noted by ultrasound examination. Physical examination revealed no palpable mass. An excisional biopsy was done, and the diagnosis was invasive micropapillary carcinoma. The patient underwent a right modified radical mastectomy with axillary dissection. Histologically, the tumor was composed of pseudopapillary structures in clear spaces lined by delicate strands of fibrocollagenous stroma. The pseudopapillary structures were devoid of fibrovascular cores. Estrogen receptor and progestrone receptor were positive in the tumor cells, C-erb-B2 and WT1 were negative. Tumor cells showed membranous and cytoplasmic expression of Ca125. In this case, we described a rare subtype of invasive ductal carcinoma and discussed the histopathological and immunohistochemical findings.

Keywords:

Breast, invasive micropapillary carcinoma, immunohistochemical examination,

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Kabul Tarihi : 28.11.2011
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