Yusuf KAYAR, Ali DUR, İskender EKİNCİ, Shute Ailia DAE

İlk Doz Lansoprazol Kullanımı Sonrası Gelişen Anafilaksi: Olgu Sunumu

İlaçla indüklenen anafilaksi ciddi allerjik veya hipersensitif reaksiyon olarak tanımlanan, hızlı başlangıçlı olabilen ve hayatı tehdit eden bir durumdur. Proton pompa inhibitörleri mide asit salınımıyla ilişkili birçok hastalıkta gastrik asit sekresyonunu azaltıcı etkileri nedeniyle sıklıkla kullanılan ilaçlardandır. Bu ilaçlar etkin, güvenli ve iyi tolere edilen ilaçlar olarak bilinmekle beraber karın ağrısı, baş ağrısı, bulantı, kusma ve ishal gibi hafif yan etkilerin yanında anafilaksi ve intertisyel akciğer hastalığı gibi hayatı tehdit eden ciddi yan etkilere de neden olabilir. Proton pompa inhibitörlerinden biri olan lansoprazol çok sık reçete edilmesine rağmen, lansoprazol kullanımına bağlı anafilaksi çok az sayıda rapor edilmiştir. Burada oral lansoprazol alımı sonrası oluşan bir anafilaksi olgusu takdim edilmiştir.

Anaphylaxis After the First Dose of Lansoprazole: A Case Report

Drug-induced anaphylaxis is a life-threatening condition that is rapid in onset anddefined as a serious allergic or hypersensitivity reaction. Proton pump inhibitors are widely used for the treatment of acid-related disorders. These drugs are known as effective, safe and well tolerated. Although these drugs are known to be safe they may lead to life-threatening side effects such as anaphylaxis and interstitial lung disease in addition to minor side effects such as abdominal pain, headache, nausea, vomiting and diarrhea. A small number of anaphylactic reactions to lansoprazole have been described, although it is a commonly prescribed drug. We describe a case of anaphylaxis induced by oral intake of lansoprazole.

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