İskender EKİNCİ, Yusuf KAYAR, Shute Ailia DAE, Ali DUR

Anaphylaxis After the First Dose of Lansoprazole: A Case Report

Drug-induced anaphylaxis is a life-threatening condition that is rapid in onset and defined as a serious allergic or hypersensitivity reaction. Proton pump inhibitors are widely used for the treatment of acid-related disorders. These drugs are known as effective, safe and well tolerated. Although these drugs are known to be safe they may lead to life-threatening side effects such as anaphylaxis and interstitial lung disease in addition to minor side effects such as abdominal pain, headache, nausea, vomiting and diarrhea. A small number of anaphylactic reactions to lansoprazole have been described, although it is a commonly prescribed drug. We describe a case of anaphylaxis induced by oral intake of lansoprazole.

İlk Doz Lansoprazol Kullanımı Sonrası Gelişen Anafilaksi: Olgu Sunumu

İlaçla indüklenen anafilaksi ciddi allerjik veya hipersensitif reaksiyon olarak tanımlanan, hızlı başlangıçlı olabilen ve hayatı tehdit eden bir durumdur. Proton pompa inhibitörleri mide asit salınımıyla ilişkili birçok hastalıkta gastrik asit sekresyonunu azaltıcı etkileri nedeniyle sıklıkla kullanılan ilaçlardandır. Bu ilaçlar etkin, güvenli ve iyi tolere edilen ilaçlar olarak bilinmekle beraber karın ağrısı, baş ağrısı, bulantı, kusma ve ishal gibi hafif yan etkilerin yanında anafilaksi ve intertisyel akciğer hastalığı gibi hayatı tehdit eden ciddi yan etkilere de neden olabilir. Proton pompa inhibitörlerinden biri olan lansoprazol çok sık reçete edilmesine rağmen, lansoprazol kullanımına bağlı anafilaksi çok az sayıda rapor edilmiştir. Burada oral lansoprazol alımı sonrası oluşan bir anafilaksi olgusu takdim edilmiştir.

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Simons FE, Ardusso LR, Bilo MB, El-Gamal YM, Ledford DK, Ring J et al. World Allergy organization anaphylaxis guidelines: summary. J Allergy Clin Immunol 2011; 127: 587.

Mullin JM, Gabello M, Murray LJ, Farrel CP, Bellows J, Wolov KR, et al. Proton pump inhibitors: actions and reactions. Drug Discov Today 2009;14: 647-60.

Esplugues JV, Marti-Cabrera M, Ponce J. Safety of proton pump inhibitors. Med Clin (Barc) 2006; 127: 709-5.

Pérez Roldán F, de los Ríos IL, Rodríguez Quinzaños E. Lansoprazole and glottis edema. Am J Gastroenterol 1999; 94: 1995.

Natsch S, Vinks MH, Voogt AK, Mees EB, Meyboom RH. Anaphylactic reactions to proton-pump inhibitors. Ann Pharmacother 2000; 34: 474-6.

Hilmer SN, Heap TR, Eckstein RP, Lauer CS, Shenfield GM. Microscopic colitis associated with exposure to lansoprazole. Med J Aust 2006; 184: 185-6.

Yang YX, Lewis JD, Epstein S, Metz DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA 2006; 296: 2947- 53.

Hwang KW, Woo OH, Yong HS, Shin BK, Shim JJ, Kang EY. Reversible lansoprazole-induced interstitial lung disease showing improvement after drug cessation. Korean J Radiol 2008; 9: 175-8.

Vlahos NP, Vavilis GK, Giannelou AG, Georgopoulou CN, Kommata VJ, Kouqias CT, et al. Hypersensitivity to proton pump inhibitors: lansoprazole-induced Kounis syndrome. Int J Cardiol 2009; 134: 94-6.

Yildirim T, Yilmaz R, Baydar DE, Kutlugun AA, Aki T, Aki T, et al. Lansoprazole induced acute allergic interstitial nephritis in a renal transplant recipient: a case report. Int Urol Nephrol 2012; 44: 1903-6.

Candar M, Gunes H, Boz BV, Kandis H, Kutlucan L, Saritas A. Asystole after first dose of lansoprazole. Am J Emerg Med 2014; 32: 1302-4.

Sobretiva Elfau MT, Garcés Sotillos M, Ferrer Clavería L, Segura Arazuri N, Mónzon Ballarin S, Colás Sanz C. Study of crossreactivity between proton pump inhibitors. J Investig Allergol Clin Immunol 2010; 20: 157-61.

Lobera T, Navarro B, Del Pozo MD, González I, Blasco A, Escudero R, et al. Nine cases of omeprazole allergy: cross-reactivity between proton pump inhibitors. J Investig Allergol Clin Immunol 2009; 19: 57-60.