Özge Göktürk MD, HATİCE BALCI YÜCE, Ahmet İNANIR, ÖZGE GÖKTÜRK, Hümeyra Aydemir TURKAL, VİLDAN BOSTANCI

Fibromiyalji Sendromu Olan Hastalarda Kronik Periodontitis, Bruksizm ve Temporamandibular Eklem Rahatsızlığı Prevalansı

Amaç: Kronik periodontitis dünya çapında yaygın bir enfeksiyöz ve enflamatuvar hastalıktır ve fibromiyalji sendromu (FMS) gibi diğer enflamatuvar hastalıklar ile bir ilişkisi olabilir. Bu çalışmanın amacı, FMS ve kronik periodontitis arasında bir ilişki olup olmadığını tespit etmektir.Gereç ve Yöntemler: Bu çalışmaya 64 FMS'li ve 70 sistemik sağlıklı hasta dahil edilmiştir. Fibromiyalji hastalarının başka bir sistemik rahatsızlığı bulunmamaktadır. Tüm hastaların detaylı oral ve radyografik incelemeleri, bruksizm ve temporomandibular eklem (TME) muayenesi gerçekleştirilmiş ve ağızlarında en az 20 fonksiyonel diş bulunduğu doğrulanmıştır. Tüm klinik ataçman seviyeleri, plak ve gingival indeks skorları kaydedilmiştir

Prevalence of Chronic Periodontitis, Bruxism and Temporomandibular Joint Disorders in Patients with Fibromyalgia

Objective: Chronic periodontitis is a world-wide infectious and inflammatory disease and may have a relationship with other inflammatory diseases such as fibromyalgia syndrome (FMS). The aim of this study was to determine whether the prevalence of periodontitis is increased in individuals with FMS or not. Materials and Methods: Sixty-four patients with FMS and 70 systemically healthy individuals were included in the present study. Fibromyalgia patients did not have any other systemically disease. All subjects had at least 20 functioning teeth and underwent detailed oral and radiographic examination, in addition, bruxism and temporomandibular joint (TMJ) examinations were performed. All clinical attachment levels, plaque and gingival indices were recorded. Results: Fibromyalgia patients tend to have higher gingival index scores than healthy individuals. There was a significant difference in the presence of bruxism between the study groups (p<0.05) but not in the presence of TMJ disorders. There was no significant difference regarding to periodontal disease between individuals under age 45 years. The prevalence of periodontitis was increased in healthy group aged above 45 years (p<0.05) but not changed in equivalent FMS patients (p>0.05).Conclusion: We found that the prevalence of periodontitis was not changed in FMS patients but was increased in healthy subjects above age 45.

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1. Wolfe F, Anderson J, Harkness D, Bennett RM, Caro XJ, Goldenberg DL, et al. Work and disability status of persons with fibromyalgia. J Rheumatol 1997; 24: 1171-8.
2. Bradley LA. Pathophysiology of fibromyalgia. Am J Med 2009; 122: 22-30.
3. Santos-Garcia R, Sanchez-Dominguez B, Cordero MD. Utility of Periodontal exploration in patients with Fibromyalgia. J Clin Exp Dent 2012; 4: 40-2.
4. Batmaz I, Sariyildiz MA, Dilek B, Inanır A, Demircan Z, Hatipoğlu N, et al. Sexuality of men with fibromyalgia: what are the factors that cause sexual dysfunction? Rheumatol Int 2013; 33: 1265- 70.
5. Barth H, Klein R, Berg PA. L-tryptophan contaminant 'peak E' induces the release of IL-5 and IL-10 by peripheral blood mononuclear cells from patients with functional somatic syndromes. Clin Exp Immunol 2001; 126: 187-92.
6. Gur A, Karakoc M, Nas K, Remzi, Cevik, Denli A, et al. Cytokines and depression in cases with fibromyalgia. J Rheumatol 2002; 29: 358-61.
7. Su SY, Chen JJ, Lai CC, Chen CM, Tsai FJ. The association between fibromyalgia and polymorphism of monoamine oxidase A and interleukin-4. Clin Rheumatol 2007; 26: 12-6.
8. Ortega E, Garcia JJ, Bote ME, Martín-Cordero L, Escalante Y, Saavedra JM, et al. Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chances. Exerc Immunol Rev 2009; 15: 42-65.
9. Geenen R, Bijlsma JW. Deviations in the endocrine system and brain of patients with fibromyalgia: cause or consequence of pain and associated features? Ann N Y Acad Sci 2010; 1193: 98- 110.
10. Di Franco M, Iannuccelli C, Valesini G. Neuroendocrine immunology of fibromyalgia. Ann N Y Acad Sci 2010; 1193: 84-90.
11. Blanco I, Janciauskiene S, Nita I. Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNFalpha), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia. Clin Rheumatol 2010; 29: 189-97.
12. Yigit S, Inanir A, Tekcan A, Inanir S, Tural S, Ates O. Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population. Gene 2013; 527: 62-4.
13. Sturgeon JA, Darnall BD, Zwickey HL. Proinflammatory cytokines and DHEA-S in women with fibromyalgia: impact of psychological distress and menopausal status. J Pain Res 2014; 7: 707-16.
14. Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000 2007; 43: 160-232.
15. Basu S, Helmersson J, Jarosinska D, Sallsten G, Mazzolai B, Barregard L. Regulatory factors of basal F(2)-isoprostane formation: population, age, gender and smoking habits in humans. Free Radic Res 2009; 43: 85-91.
16. D'Aiuto F, Nibali L, Parkar M, Patel K, Suvan J, Donos N. Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res 2010; 89: 1241-6.
17. Cordero MD, Moreno-Fernandez AM, deMiguel M, Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia. Clin Biochem 2009; 42: 732-5.
18. Bagis S, Tamer L, Sahin G. Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Rheumatol Int 2005; 25: 188-90.
19. Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL, et al. Oxidative stress in fibromyalgia and its relationship to symptoms. Clin Rheumatol 2009; 28: 435-8.
20. Ozgocmen S, Ozyurt H, Sogut S, Akyol O. Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide. Rheumatol Int 2006; 26: 585-97.
21. Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Giuliano T, De Feo F, et al. Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatol 2007; 25: 225-30.
22. Uceyler N, Hauser W, Sommer C. Systematic review with meta-analysis: cytokines in fibromyalgia syndrome. BMC Musculoskelet Disord 2011; 12: 245.
23. Tsilioni I, Russell IJ, Stewart JM, Gleason RM, Theoharides TC. Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells. J Pharmacol Exp Ther 2016; 356: 664-72.
24. Mendieta D, la Cruz-Aguilera DL, Barrera-Villalpando MI, Becerril-Villanueva E, Arreola R, Hernandez-Ferreira E, et al. IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients. J Neuroimmunol 2016; 290: 22-5.
25. Bote ME, Garcia JJ, Hinchado MD, Ortega E. Inflammatory/ stress feedback dysregulation in women with fibromyalgia. Neuroimmunomodulation 2012; 19: 343-51.
26. Cekici A, Kantarci A, Hasturk H, Van Dyke TE. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000 2014; 64: 57-80.
27. Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol 2003; 74: 391-401.
28. Graves DT, Fine D, Teng YT, Van Dyke TE, Hajishengallis G. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol 2008; 35: 89- 105.
29. Garlet GP, Martins W, Jr., Fonseca BA, Ferreira BR, Silva JS. Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal disease. J Clin Periodontol 2004; 31: 671-79.
30. Okada N, Kobayashi M, Mugikura K, Okamatsu Y, Hanazawa S, Kitano S, et al. Interleukin-6 production in human fibroblasts derived from periodontal tissues is differentially regulated by cytokines and a glucocorticoid. J Periodontal Res 1997; 32: 559- 69.
31. Kwan Tat S, Padrines M, Theoleyre S, Heymann D, Fortun Y. IL6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev 2004; 15: 49-60. 32. Dinarello CA. Proinflammatory cytokines. Chest 2000; 118: 503- 8.
33. Markkula RA, Kalso EA, Kaprio JA. Predictors of fibromyalgia: a population-based twin cohort study. BMC Musculoskelet Disord 2016; 17: 29.
34. Balasubramaniam R, Laudenbach JM, Stoopler ET. Fibromyalgia: an update for oral health care providers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104: 589-602.
35. Kato M, Saruta J, Takeuchi M, Sugimoto M, Kamata Y, Shimizu T, et al. Grinding patterns in migraine patients with sleep bruxism: a case-controlled study. Cranio 2016; 34: 371-7.
36. Kostrzewa-Janicka J, Jurkowski P, Zycinska K, Przybylowska D, Mierzwinska-Nastalska E. Sleep-Related Breathing Disorders and Bruxism. Adv Exp Med Biol 2015; 873: 9-14.
37. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999; 4: 1-6.
38. Silness J, Loe H. Periodontal Disease in Pregnancy. II. Correlation between Oral Hygiene and Periodontal Condtion. Acta Odontol Scand 1964; 22: 121-35.
39. Loe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 1967; 38: (Suppl): 610-6.
40. Lobbezoo F, Ahlberg J, Glaros AG, Kato T, Koyano K, Lavigne GJ, et al. Bruxism defined and graded: an international consensus. J Oral Rehabil 2013; 40: 2-4.
41. Medicine AAoS. Diagnostic and Coding Manual. 2nd ed. Westchester, IL, USA, 2005.
42. Dworkin SF, Le Resche L. Research diagnostic criteria for temporomandibular disorders:review, criteria, examinations and specifications, critique. J Craniomandib Disord 1992; 6: 301-55.
43. Buergers R, Kleinjung T, Behr M, Vielsmeier V. Is there a link between tinnitus and temporomandibular disorders? J Prosthet Dent 2014; 111: 222-7.
44. Ebersole JL, Graves CL, Gonzalez OA, Dawson D, Morford LA, Huja PE, et al. Aging, inflammation, immunity and periodontal disease. Periodontol 2000 2016; 72: 54-75.
45. Gurbuzler L, Inanir A, Yelken K, Koc S, Eyibilen A, Uysal IO. Voice disorder in patients with Fibromyalgia. Auris Nasus Larynx 2013; 40: 554-7.
46. Fujarra FJ, Kaziyama HH, Siqueira SR, Yeng LT, Camparis CM, Teixeira MJ, et al. Temporomandibular disorders in fibromyalgia patients: are there different pain onset? Arq Neuropsiquiatr 2016; 74: 195-200.
47. de Baat C, Gerritsen AE, de Baat-Ananta M, de Baat P. [The (putative) pathological impact of fibromyalgia on the orofacial system]. Ned Tijdschr Tandheelkd 2016; 123: 148-53.
48. Ghurye S, McMillan R. Pain-Related Temporomandibular Disorder - Current Perspectives and Evidence-Based Management. Dent Update 2015; 42: 533-45.
49. Balasubramaniam R, Laudenbach JM, Stoopler ET. Fibromyalgia: an update for oral health care providers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104: 589-602.
50. Atzeni F, Masala IF, Salaffi F, DiFranco M, Casale R, Sarzi - Puttini P. Pain in systemic inflammatory rheumatic diseases. Best Pract Res Clin Rheumatol 2015; 29: 42-52.
51. Reddy MS, Geurs NC, Gunsolley JC. Periodontal host modulation with antiproteinase, anti- inflammatory, and bone-sparing agents. A systematic review. Ann Periodontol 2003; 8: 12-37.