Aripiprazol’a Bağlı Parkinsonizm: İki Olgu Sunumu
Aripiprazoli şizofreni, depresyon, bipolar bozukluk ve parkinson hastalığında kullanılan yeni kuşak antipsikotiklerdendir. En iyi bilinen yan etkileri arasında insomni, anksiyete, baş ağrısı, bulantı, kusma ve somnolans yer alır. Aripiprazol sık olmayan ekstrapiramidal yan etkilerle ilişkilidir. Bazı ilaçların dopaminerjik reseptörleri blokajı sonucu parkinsonizm tablosu ortaya çıkabilmektedir. İlaca bağlı parkinsonizm de belirtiler genelde subakut yerleşir ve tabloya genel de akinetik-rijid bir sendrom hakim olur. Parkinsonizm belirtileri, kural olarak ilacın kesilmesiyle birkaç ay içinde kaybolur. Aripiprazol dopamin sistemini dengeleyici ilaçlar grubundadır, böylece daha az ekstrapiramidal yan etki profiline sahip olduğu öne sürülmektedir. Bu yazıda aripiprazol ilişkili parkinsonizmli iki olgu sunulmuştur
Anahtar Kelimeler:
Antipsikotik, aripiprazol, parkinsonizm, yan etki
Aripiprazole-Induced Parkinsonism: Report of Two Cases
Aripiprazole is one of the recently introduced atypical antipsychotics used in the treatment of psychosis related to schizophrenia, depression, bipolar disorder, and Parkinson’s disease. Well-documented side effects associated with the use of aripiprazole include insomnia, anxiety, headache, nausea, vomiting, and somnolence. Aripiprazole is associated with infrequent extrapyramidal side effects. Parkinsonism is caused by some drugs that block dopamine receptors. The sign of drug-induced parkinsonism (DIP) has a subacute onset and the clinical picture is usually dominated by akinetic-rigid symptoms. The symptoms of parkinsonism generally disappear within a few months after cessation of the drug. Aripiprazole, a dopamine system stabilizer, has fewer extrapyramidal side effects than typical antipsychotics. In this paper, we present two cases of aripiprazole-induced parkinsonism.
Keywords:
Antipsychotic, aripiprazole, parkinsonism, side effect,
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- ISSN: 2149-9063
- Başlangıç: 2000
- Yayıncı: Erkan Mor
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