Setyawan DWİ, Setiawardani FEBRİANTİ, Amrullah ZAİNUL, Sari RETNO

PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system

The aim of this study was to examine the physical characteristics, solubility, and in vitro dissolution profile of quercetin-PEG 8000 solid dispersion prepared by melting method. Solid dispersion was prepared by melting method with various ratios of quercetin and PEG 8000 (1:1; 1:2; 1:3). The solid dispersion was characterized using differential thermal analyzer (DTA), powder X-ray diffraction (PXRD), scanning electron microscope (SEM), and fourier transform infrared spectroscopy (FTIR). The solubility and in vitro dissolution of quercetin-PEG 8000 solid dispersion were evaluated and compared to physical mixture and pure quercetin. The solid dispersion of quercetin-PEG 8000 has lower melting point and crystal peak intensity compared to pure quercetin and physical mixture. The infrared spectra of solid dispersions and physical mixtures indicated the occurrence of physical interactions that involved weak bonding forces such as the hydrogen bond between quercetin functional groups and O-H group. The solubility and the dissolution rate enhanced in accordance with increasing of PEG 8000 amount.

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