The effect of lithium chloride and calcium antagonists (nifedipine and diltiazem) on brain lipid peroxide and glutathione levels were investigated in mice.When nifedipine and diltiazem were administered separately brain lipid peroxide levels did not change, but nifedipine and diltiazem administration together with lithium chloride led to a significant decrease in the brain lipid peroxidation stimulated by lithium chloride.