T1 relaxation time in the evaluation of liver fibrosis; with native MR relaxometry
T1 relaxation time in the evaluation of liver fibrosis; with native MR relaxometry
Objective: Non-invasive methods have been investigated as an alternative to biopsy in assessing liver fibrosis. This study aimed to
evaluate the relationship between liver T1 relaxation time and liver fibrosis as a non-invasive alternative method.
Patients and Methods: This study analyzed 1.5T magnetic resonance (MR) images of 86 patients retrospectively. The participants were
divided into two groups: patients with chronic hepatitis and the control group. Native variable flip angle (VFA) T1 mapping technique
was used to estimate liver T1 relaxation time. T1 mapping sequence, T2* mapping sequence, and image analysis were performed. The
liver size, the spleen size, the liver T1 relaxation time, and the liver T2* relaxation time were recorded.
Results: The T1 relaxation time was 758.4 ± 121.1 ms in the chronic hepatitis group and 600.2 ± 67 ms in the control group. The T1
relaxation time of the patient group was significantly higher than that of the control group (p<0.001). The spleen size of the patient
group was statistically significantly larger than the control group (p<0.001). There was a significant positive correlation between liver
T1 relaxation time and Ishak score (r=0.683, p<0.001). Also, a significant positive correlation was observed between T1 relaxation time
and histological activity index score (r=0.542, p<0.001).
Conclusion: A native T1 map is a non-invasive method that works as an alternative to biopsy in the follow-up and diagnosis of chronic
hepatitis. Moreover, this method can be used to measure liver T1 relaxation time in patients with liver fibrosis.
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