Serbest radikaller, süt serumu proteinleri ve kolorektal kanser

Kolorektal kanser etiyolojisinde diyetin önemli bir çevresel faktör olduğu yapılan çalışmalarla kanıtlanmıştır. Total enerji alımı, yüksek yağlı diyet ve kırmızı et alımı ile kolon kanseri gelişimi arasında bağlantı olduğu epidemiyolojik verilerle de desteklenmiştir. Batı tarzı diyet ve pişirme teknikleri kolon kanseri için risk faktörü olarak yer almaktadır. Öte yandan, reaktif oksijen türleri tarafından oluşturulan oksidatif stres, kanser ve nörodejeneratif bozukluklar gibi yaşa bağlı hastalıklarda önemli rol oynamaktadır. Süt serumu proteinleri ve diğer diyetsel proteinlerin reaktif oksijen radikallerini temizleme gücüne sahip olduğu bildirilmiştir. Hayvan çalışmalarında karsinojen kullanılarak oluşturulan kolon kanserine karşı süt serumu proteinlerinin koruyucu olduğu gösterilmiştir. Proteinlerin yanında protein hidrolizatlarının da antioksidan aktivite gösterdiği bulunmuştur. Protein hidrolizi sırasında proteinin tersiyer yapısının bozulması ve amino asit salınmasındaki artışa bağlı olarak proteinin antioksidan aktivitesinde artış izlenmektedir. Bu derlemede, kolorektal kanser etiyopatogenezindeki mevcut bilgileri özetlemeye ve tedavide süt serumu proteinlerinin potansiyel kullanımını irdelemeye çalıştık.

Free radicals, whey proteins and colorectal cancer

Evidence that has accumulated for many years suggests that diet isan important environmental factor in the etiology of colorectalcancers. Epidemiological data generally support the associationbetween total energy intake, high fat diets, red meat intake andincreased colon cancer risk. The Western-style diet and cookingtechniques are risk factors for developing colon cancer. Further,oxidative stress caused by reactive oxygen species plays asignificant role in a number of age-specific diseases such as cancerand neurodegenerative disorders. Dietary proteins including wheyproteins have been reported to have the ability to scavenge reactiveoxygen species. Animal studies have also shown that whey proteinprotects against the development of carcinogen induced colontumors in rats. In addition to proteins, protein hydrolyzates havebeen found to exhibit antioxidant activity. During proteinhydrolysis, overall antioxidant activity of protein is enhanced as itstertiary structure is disrupted and the solvent accessibility ofreleased amino acids increases. In this review, we summarize thepresent knowledge on the etiopathogenesis of colorectal cancersand the potential use of whey proteins in its treatment.

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Marmara Medical Journal-Cover
  • ISSN: 1019-1941
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1988
  • Yayıncı: Marmara Üniversitesi
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