Objective: In this retrospective study, we evaluated the ability of preoperative parameters to predict tumor significance in men with stage T1c disease who underwent radical retropubic prostatectomy. Patients and Methods: A total of 26 consecutive patients who underwent radical retropubic prostatectomy owing to clinically localized disease fulfilled the criteria for insignificant cancer namely PSA density lower or equal to 0.10, presence of Gleason grade