The results of isosorbide treatment which was used in twenty patients who had been diagnosed as Meniere’s disease were presented. Isosorbide was found most effective on the control of vertigo (% 70). The hearing improvement was observed in five patients, however it was temporary, returning to . its ' pretreatment levels after treatment. Isosorbide is a drug which should be chosen in the treatment of the acute attack of Meniere’s disease.