Spinal epidermoid tumors represent less than 1% of all spinal tumors. The vast majority are subdural and extramedullary. Intramedullary epidermoid tumors are extremely rare. There are 54 intramedullary epidermoid tumors reported in literature. Epidermoid tumors, though seen rarely, must be considered in differential diagnosis of intramedullary mass lesions and the choise for diagnostic test must be Magnetic Resonance Images (MRI). We report two cases of intramedullary epidermoid tumor located in lumbar and thoracic region with the review of the literature.