There is a controversy in administering fluid therapy containing glucose intraoperatively to neurosurgical patients. Patients with intracranial mass already face the risk of cerebral hypoperfusion. To study the effects of intraoperative glucose administration of postoperative outcome, different fluid therapy was administered to each of three groups of patients undergoing craniotomy. One group received physiological saline (PS), the second group received Ringer solution without lactate (R), and the third group received 5% dextrose solution (D). Venous blood levels of glucose, lactic acid, pyruvic acid, Bhydroxybutyric acid ( (3HBA), sodium, potassium, chrolide, acetone, and arterial pC02, p02, and bicarbonate were estimated at induction of anaesthesia and 6, 12, 24, 48 hours postoperatively. Urinary acetone was also estimated. Obtained values were compared between the groups and their relation to each other were analyzed within each group. Blood glucose rose in all three groups but no significant difference was found in the glucose levels among the three groups, contrary to what has been expected.