DOOPLER ULTRASONOGRAPHY IN EVALUATING THE ENDOMETRIUM OF POSTMENOPAUSAL WOMEN RECEIVING HRT

DOOPLER ULTRASONOGRAPHY IN EVALUATING THE ENDOMETRIUM OF POSTMENOPAUSAL WOMEN RECEIVING HRT

Objective: In this study we investigated the value of Doppler ultrasonography (DUSG) in evaluating the endometrium of postmenopausal women receiving hormone replacement therapy (HRT).Material and Method: Sixty-five postmenopausal women constituted the material of our study. Pelvic DUSG was used to evaluate endometrial thickness and resistance index (Rl) values before and after one year of hormone replacement therapy HRT. Forty-two patients completed the study and statistical analysis was performed using paired t-test and variables using multiple regression analysis.Results: Endometrial thickness was measured as 3.5(1.5 mm after one year of therapy. The increase in thickness was statistically significant (p<0.05)). Although there was a slight decrease in Rl values, this finding was not considered to be statistically significant (p>0.05).Conclusion: In this study we concluded that uterine artery Rl does not change significantly after HRT; this conclusion contradicts other studies in the literature. This difference may be due to the short duration of menopause in our study group.Key Words: Doppler ultrasonography,Menopause, HRT

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  • Danska A, Szpurek D, Kedzia IT, Spaczynshi N. Doppler USG for detection of pathologic changes In uterine body endometrium. Ginekol-Pol 1997; 68: 604-609.
  • Bourne T, Campbell S, Steer CV, Hoys ton H. Detection of endometrial cancer by TV USG with color flow imaging and blood flow analysis. A preliminary report. Gynecol Oncol 1991; 40:253-225.
  • Hotmensch S, Copel JA, flobblns JC. Introduction to Doppler Velocimetry In obstetrics. Obstet Gynecol Clin ITorth-Am 1991; 18:823-843.
  • Pleischer AC. Sonography in Obstetrics and Gynecology. Principles and Practice.flew Jersey: Appleton and Lange, 1996:863-864
  • Kurjak A. Endometrial carcinoma in postmenopausal women. Evaluation by TV color Doppler USG. Am J Obstet Gynecol 1993; 169:1597-1603.
  • 7 7
  • N u re t t in Aka, et al.
  • Kurjak A, Kupesic S. Ovarian senescence and its significance on uterine and ovarian perfusion. Fertil Sterii 1995; 64:532-537.
  • Bonilla MF, Marti MC, Ballester MJ, Raga F. normal uterine arterial blood flow in postmenopausal women assessed by TV color Doppler sonography: the effect of fIRT. J Ultrasound Med 1995; 14:497-501.
  • Jakap A Jr. Management of menopause and fIRT by ultrasound. Eur J Obstet Gynecol Re prod Biol 199 7; 71:155-162.
  • Van Baal WM, Kenemans P, Stehouwer CD, Peters-Muller ER, van Vugt JM, van der Mooren MJ. Sequentially combined hormone replacement therapy reduces impedance to flow within the uterine and centra! retinal arteries in healthy postmenopausal women. Am J Obstet Gynecol 1999; 181:1365-1373.
  • Tanawattanacharoen S, Panyakhamlera K, Chaikittisilpa S, Taechakraichana 3, Limpaphayom KK. Uterine blood flow response to hormonal replacement therapy in asymptomatic postmenoausal women: a transvaginal Doppler Study. J Med /Issoc Thai 2000; 83:368-373.
  • Zalud I,Conway C.Shulman tl.Trinca D.
  • Endometrial and myométrial thickness and uterine blood flow in postmenopausal women: the influence of hormonal
  • replacement therapy and age. J Ultrasound Med 1993;12:737-741.
  • Doren M, Suselbeck B, Schneider UP, tlolzgreve W. Uterine perfusion and
  • endometrial thickness in postmenopausal women on long-term continuous combined estrogen and progestogen replacement. Ultrasound Obstet Gynecol 1997; 9:1 13-119.
  • Bekavac I, Kupesic S, Mihaljevic D, Kurjak A. Vascular impedance of uterine, inferior vesicle, and ophthalmic arteries in postmenopausal women receiving hormonal replacement therapy: comparative Doppler study.Croat Med J 2000;41:235-239.
  • Varner RE, Sparks JM, Cameron JD, Roberts LL, Soongs J. Transvaginal sonography of the endometrium in postmenopausal women. Obstetrics Gynecol 1991; 78:195-199.
  • Jones KP. Estrogens and progestins: What to use and how to use it. Clinical Obstet Gynecol 1992; 35:871-883.
  • Sobel FIB. Progestins in preventive hormone
  • therapy. Including pharmacology of the
  • new progestins, desogestrel, norgestimate, and gestodene: are there advantages? Obstet Gynecol Clin Korth Am 1994; 21:299-319.
  • 7. Coiditz GA, Elgan KM, Stampfer MJ. IIRT and risk of breast cancer. Results from epidemiologic studies. Am J Obstet Gynecol 1993; 168:1473-1480.
  • Steth 5, Hamper UM, McCollum ME, Caskey Cl, Rosenshein 3B, Kurman RJ. Endometrial blood flow analysis in postmenopausal women: Can it help differentiate benign from malignant causes of endometrial thickening? Radiology 1995; 195:661-665.