Objective: It is accepted that sedation during endoscopic procedures is mandatory in children, however the mode of sedation and choice of medication varies among gastroenterologists. The use of intravenous sedation in pediatric endoscopy offers a safe and effective way of either conscious or deep sedation. Methods: In order to investigate the safety and efficacy of intravenous sedation with meperidine and midazolam in pediatric patients, 120 patients who underwent endoscopy were evaluated. Vital signs and any reaction to sedative agents were noted during and after the endoscopic procedure. Results: The complication rate of sedation with this combination was 19.1%, and all were transient with no residual sequelae. The most common complication was allergic skin reactions (15.7%). Transient hypoxia was seen in 1.7% of patients. The recovery time was 74.8±15.8 min. The endoscopic procedure was not postponed in any of the patients due to the complication of sedation. Conclusion: It was concluded that intravenous deep sedation with meperidine and midazolam when administered by an experienced pediatric gastroenterologist and monitored closely is safe and effective with a low risk of complication.