Restrictive cardiomyopathy due to cardiac amyloid deposition is not an uncommon complication of multiple myeloma. Most cases of cardiac amyloidosis reported in early series were diagnosed postmortem at autopsy(1,2). The following is a report of a case with antemortem diagnosis of cardiac amyloidosis as a complication of multiple myeloma. We described the clinical features and diagnostic approaches by review of the literature.