C. Selim İSBİR, Rıza DOĞAN, Metin DEMİRCİN, İlhan PAŞAOĞLU

Aprotinin improves Ca2+ - Mg2+ / ATPase levels in ischemia-reperfusion injury

Anahtar Kelimeler:

Ca(2+) Mg(2+)-ATPaz, Aprotinin, Reperfüzyon hasarı, İskemi, Eritrosit membranı

Objective: The aim of this study is to determine the effect of aprotinin, on calcium activated and magnesium dependent adenosine 5' triphosphatase (Ca2+-Mg2VATP ase) levels. Methods: Twenty patients who had elective coronary artery bypass grafting (CABG) were randomly divided into two groups (n= 10, in each). Group A patients received full dose aprotinin (20 000 lU/kg as pretreatment followed by 7500 lU/kg for 6 hours) and Group B patients received normal saline as control group. Erythrocyte membrane Ca2+-Mg2VATP ase levels were measured. Results: Ca2+-Mg2+ /ATPase levels were protected in aprotinin group, 807.60+32.62 vs 634.28+22.91 (p<0.05) at post-operative 24th hour. (p<0.05). Conclusion: Aprotinin protected the erythocyte membrane Ca2+-Mg2+ ATP/ase from oxidant stress thus it might affect the cell membrane stabilization. ,

Keywords:

Ca(2+) Mg(2+)-ATPase, Aprotinin, Reperfusion Injury, Ischemia, Erythrocyte Membrane,

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