After the description of Progressive Supranuclear Palsy (PSP) by Steel-Richardson and Olszewski, in 1964 even though there are many publications about the clinical state and the morphology of the disease the pathogenesis of the disorder is still unclear.In this study. 5 PSP patients were investigated clinically. by using the neuroscientific method and the morphological parameters and the etiopathogenesis has been discussed in the light of the new investigation methods.