The hepatic protective effect of intravenous verapamil in dogs (n=8) during halothane anesthesia in hypoxic conditions was observed. The protective potential was defined by both histopatholu^ a! evaluation and serum en/.yme level measurements. Mean alkaline phosphatase and lactic dehydrogenase enzyme levels in the group administered with calcium channel blocker-verapamil were noted,although not statistically significant, to be lower than those of the control group.Further prcnchymal injury during histopathological evaluation using the light microscope were noted to be significantly less in the verapamil group administered when compared to the control group.