The changes in static acoustic impedance (SAI) after the ingestion of glycerol in the patients with Meniere's disease are presented. Two groups of subjects are studied. Group A consisted of 24 patients with Meniere's disease. Group B included 10 normal subjects. Each subject underwent a pre-glycerol audiologic test. After the ingestion of glycerol, final audiologic tests were performed. The pure tone thresholds, speech discrimination scores and also the static acoustic impedance results were recorded. Significant decrease in SAI in Group A patients was observed. Group B subjects failed to show a remarkable change in SAI. The post-glycerol decrease in SAI is an important finding and it is significantly correlated with the improvements in pure tone thresholds and speech discrimination scores in Meniere's disease.