Results of intravenous immunoglobulin administration in childhood itp

One chronic and 10 acute ITP patients, admitted tothe GATA Haydarpaşa Training Hospital PediatricClinic between February 1989 - February 1993 weretreated by IVIG in doses of 0.5 g/kg for 5 days. Sevenof the patients were female and 4 were male. Themean age was 4.8 years (2 months - 9 years). Noneof the patients revealed a maternal ITP history.Thrombocyte levels (mean 18,090 ± 7,634/mm3) atadmission rose sharply within 3 days and reachedhemostatic levels on the 5th day (mean 231,272 ±156,770/mm3). These levels were checked on the10th, 30th, 150th day and the average was found tobe over 150,000/mm3.One patient (a 6 year old girl) who gave goodresponse to initial IVIG diagnosed as acute ITP hasshown recurrences. These attacks responded to IVIGtreatment well and splenectomy was not needed. Weobserved no reccurences in the other 10 cases. Noside effects relating to IVIG were reported.IVIG therapy can be considered as a safe approachto childhood ITP, quickly restoring the hemostaticthrombocyte levels and thus preventing lifethreateningcomplications such as intracranialhemorrhage in acute ITP and leading to favorableremission periods in chronic ITP.

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