Outpatient endometrial sampling, using the Pipelle endometrial biopsy device, is an alternative procedure for dilatation of the cervix and curettage (D&C). In this study we compared the reliability of the Pipelle with D&C, in women with pre and post menopausal bleeding and 90.3 % was considered to be successful. Insufficent material was obtained in22.6 % of cases with Pipelle whereas with D&C 12.9% provided inadequate tissue. The Pipelle is associated with minimal pain, haemorrage, does not require anesthesia and is much cheaper, acceptable and convenient for most patients. Our results show that this method can be used for outpatient endometrial sampling