___

• Hepler JR, Gilman AG. G proteins. Trends Biochem Sci 1992;17:383-387.
• Rens-Domiano S, Hamm HE. Structural and functional relationships of heterotrimeric G- proteins. FASEB J 1995;9:1059-1066.
• Offermans S, Simon Ml. Organization of transmembrane signalling by heterotrimeric G proteins in Cancer Surveys. Cell Signalling. Tooze J. Parker PJ, Pawson T eds. HewYork: Cold Spring Harbor Laboratory Press, 1996:177-198.
• Heer E. Heterotrimeric G proteins: Organizers of transmembrane signals. Cell ¡995:80:249-257.
• iioel JP, Hamm HE, Sigler PB. The cryctal structure of the GTP y S - bound alpha subunit of the rod G protein, nature 1993:366:654-663.
• Lambright DG, Hoe! JP, Hamm HE, Sigler PB. The 1.8A cysta! structure of transducin a-GDP. Structural determinants for activation of a heterotrimeric G- protein a subunit, nature 1994:369:621-628.
• Gilman AG, G proteins: Transducers of receptorgenerated signals. Annu Rev Biochem 1987;56:615-649.
• Logothetis DE, Kurachi Y., Galper J., neer EJ, Clapham DE. The fiy subunits of GTP - binding proteins activate the muscarinic K+ channel in heart, nature 1987:325:321-326.
• Clapham DE, neer EJ, new roles for G protein Py dimers in transmembrane signaling, nature 1993:365:403-406.
• Malbon CC. Heterotrimeric G-proteins and development. Biochem Pharmacol 1997:53:1-4.
• Strittmater SM, Valenzuela D, Kennedy TE, neer EJ, Eishman PIC. Gocr is major growr cone protein subject to regulation by GAP-43. nature 1990;344:836-84!.
• Marmara Medical Journal Volume 12 No: 1 January 1999
• Strittmater SM, Valenzuela D, Kennedy TE, rieer EJ, Fishman MC. Mediation by G-proteins of signals that cause collapse of growth cones. Science 1993:77- 79.
• Mullaney I, Milligan G. Elevated levels of the guanine nucleotide binding protein, G0, are associated with differentiation of neuroblastoma x glioma hybrid cells. FEBS Lett 1989,244:113-118.
• Gierschik F, Morrow B, Milligan G, Rubin C, Spiegel A. Changes in the guanine nucleotide-binding proteins, G,- and G0, during differentiation of 3T3-LI cells. FEBS Lett 1986; 199:103-106.
• Watkins DC, Rapiejko PJ, Ros M, Wang Fl, Malbon CC. G-protein mRITA levels during adipocyte differentiation. Biochem Biophys Res Commun. 65:929-934.
• Wang FI, Watkins DC, Malbon CC. Antisense oligodeoxynucleotides to Gs protein cx-subunit sequence accelerate differentiation of fibroblasts to adipocytes, nature 1992;358:334-337.
• Denis-Ftenriot D., Lacasa D, Goldsmith PK, De Mazancourt P, Giudicelli Y. Site-related differences in G-protein a subunit expression during adipogenesis in vitro: Possible key role for Gq/I / a in the control of preadipocyte differentiation. Biochem Biophys Res Commun 1996:220:443-448.
• Galvin-Parton PA, Watkins DC, Malbon CC. Retinoic acid modulation of transmembrane signaling. Analysis in F9 teratocarcinoma cells. J Biol Chem 1990;265:17771-17774.
• Gao P, Malbon CC. Differentation of F9 teratocarcinoma stem cells to primitive endoderm is regulated by the Gia2/Gsa axis via phospholipase C and not adenylyl cyclase. J Biol Chem 1996:2 71:3069 7-30698.
• Amatruda TT, Steele DA, Zlepak VZ, Simon Ml. Cin 16, a G protein a subunit specifically expressed in hematopoietic cells. Proc ITatl Acad Sci USA 1991;88:5587-5591.
• Meibner JD, Brown G A, Mueller WFI, Scheibe RJ. Retinoic acid -mediated decrease of Gas protein expression Involvement of Gas in the differentiation of tlL-60 myeloid cells. Exp Cell Res 1996:225:1 12-121.
• Tiagata K, Okano Y, ITozawa Y. Identification of heterotrimetric GTP-binding proteins in human megakaryoblastic leukemia cell line, MEG-01, and their alteration during cellular differentiation. Life Sci 1995;57:1675-1681.
• Kesselring F, Spicher K, Porzig FI. Changes in G protein pattern and in G protein -dependent signaling during erythopoietin- and dimethylsulfoxide- induced differentiation of murine erythroleukemia cells. Blood 1994;84:4088-4098.
• Tenailleau S, Corre I, Flermouet S. Specific expression of heterotrimeric G proteins G ¡2 and G ¡g during human myeloid differentiation. Exp Flematol 1997;25:927-934.
• Spiegel AM, Shenker A, Weinstein LS. Receptor- effector coupling by G-proteins: Implications for normal and abnormal signal transduction. Endocr Rev 1992;13:536-565.
• Spiegel AM. Defects in G protein- coupled signal transduction in human disease. Annu Rev Physiol 1995;58:143-1 70.
• Lyons J. Landis CA, Flarsh G, Vallar L et al. Two G protein oncogenes in human endocrine tumors. Science 1990;249:655-659.
• dementi E, Malgaretti H, Meldolesi J, Taramelli R. A new constitutively activating mutation of the Gs protein a subunit-gsp oncogene is found in human pituitary tumors. Oncogene 1990;5:1059-1061.
• OSullivan C, Barton CM, Staddon SL, Brown CL, Lemoine FIR. Activating point mutations of the gsp oncogene in human thyroid adenomas. Molecular Carcinogenesis 1991:4.345-349.
• Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. IT Engl J Med 1991 ;325:1688-1695.
• Scwindinger WF, Francomano CA, Levine MA. Idenfiction of a mutation in the gene encoding the a subunit of the stimulatory G protein of adenylyl cyclase in Me Cune- Albright Syndrome. Proc ITatl Acad Sci USA 1992;89:5152-5156.
• Suarez FIG, du Villard JA, Caillou B, Schlumberger M, Parmentier C, Monier R. gsp mutations in human thyroid tumors. Oncogene 1991;6:677-679.
• Tordjman K, Stern IT, Ouaknine G et al. Activating mutations of the Gsa gene in non-functioning pituitary tumors. J Clin Endocrinol Metab 1993;77:765-769.
• Yoshimato K, Iwahana FI, Fukuda A, Sano T, Itakurra M. Rare mutations of the Gsa subunit gene in human endocrine tumors. Cancer 1993:72:1386- 1393.
• Williamson EA, Daniels M, Foster S, Kelly WF, Kendall-Taylor P, Harris PE. Gsa and Cij2u mutations in clinically non-functioning pituitary tumors. Clin Endocrinol 1994;41:815-820.
• Williamson EA, Ince PG, Flarrison D, Kendall-Taylor P, Harris PE. G-protein mutations in human pituitary and adrenocorticotrophic hormone-secreting adenomas. Eur. J. Clin Invest 1995;25:128-131.
• Williamson EA, Johnson SJ, Foster S, Kendall-Taylor P, Harris PE. G-protein gene mutations in patients with multiple endocrinopathies. J Clin Endocrinol Metab 1995:80:1702-1705.