This work provides a cumulative review of the scientific results over the past 10 years on the biotechnology science. During this period we have developed the biotechnology methods to use the natural and selected microorganisms to produce environmentally friendly biological preparations to protect the agricultural and forest biodiversity from disease and pests; to increase their resistance to various stressful environmental factors. Also the biological stimulation preparations were developed for growth stimulation of cereals, vegetables and industrial crops. We have developed technology to produce the biological preparations for bioremediation of soil pollution by heavy metals and petroleum products