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Servikal Sitoloji Anormalliğinde Human Papilloma Virus ile Endoservikal Örnekleme Prevalansının Araştırılması–Vaka Kontrol Çalışması

GİRİŞ: Servikal kanser dördüncü sıklıkta görülen ve önlenebilir bir kanserdir. Bu nedenle birçok tarama programı geliştirilmiştir. Çalışmamızda anormal servikal sitolojide anormal endoservikal patoloji ve Human Papilloma Virus (HPV) prevalansını ve endoservikal örneklemenin önemini saptamayı amaçlamış bulunmaktayız. MATERYAL-METOD: Çalışmamız Ocak 2013 ve Nisan 2016 tarihleri arasında Aydın Adnan Menderes Üniversitesi Hastanesinde yapılmıştır. Çalışmamız HPV DNA bakılmış ve endoservikal küretaj ile örneklem yapılmış hastalar üzerinde yapılmıştır. Servikal sitoloji anormalliği olan hasta 215 hasta ile 175 kontrol grubu mevcuttur. Servikal sitoloji Bethesda 2001 sınıflandırma sistemine göre yorumlanmıştır. SPSS 18.0 for Windows programı ile istatiksel analiz yapılmıştır. BULGULAR: Çalışmamız 390 olgu üzerinde yapılmıştır. 215(%55) hastada anormal Pap smear, 175 (%45) hastada normal Pap smear saptanmıştır. Olguların ortalama yaşı 45.5±9 olarak saptanmıştır. Anormal Pap smearli olgularda HPV pozitifliği prevalansı %68.8, endoservikal örneklem patoloji prevalansı %40 olarak bulundu. Kontrol grubunda HPV pozitifliği prevalansı %53.7 idi. Endoservikal örneklem sonucu anormal olan hastaların prevalansı %2.8’idi. Anormal smear sitolojisi ile HPV DNA pozitifliği arasında istatistiksel olarak anlamlı ilişki saptandı (p=0.002). Servikal sitoloji anormalliği ile anormal endoservikal örnekleme patoloji sonuçları karşılaştırıldığında sonuç istatistiksel olarak anlamlı bulundu (p˂0.001). Servikal sitoloji anormalliğinin derecesi arttıkça endoservikal örneklem anormallikleri ve HPV DNA pozitifliğinin sıklığında artma olduğu görüldü (p=0.002). SONUÇ: HPV pozitifliği servikal sitoloji anormalliği ile ilişkili bulunmuştur. Anormal servikal sitoloji ile anormal endoservikal patoloji arasında anlamlı ilişki bulunmuştur. Servikal sitoloji anormalliğinin derecesi arttıkça endoservikal örneklem anormallikleri ve HPV DNA pozitifliğinin sıklığında artma olduğu saptanmıştır.
Anahtar Kelimeler:

Anormal Smear, HPV, Endoservikal Örnekleme, Serviks Kanseri

Investigation of the Prevalence of Human Papilloma Virus and Endocervical Sampling in Cervical Cytology Abnormalities–Case-Control Study

AİM: Cervical cancer is the fourth most common and preventable cancer. For this reason, many scanning programs have been developed. In this study, we aimed to determine the prevalence of abnormal endocervical pathology and Human Papilloma Virus (HPV) and the importance of endocervical sampling in abnormal cervical cytology. MATERİALS-METHODS: Our study was conducted in Aydın Adnan Menderes University Hospital between January 2013 and April 2016. 215 patients with abnormal cervical cytology who underwent HPV DNA screening and endocervical sampling were compared with 175 control group patients. Cervical cytology was interpreted according to the Bethesda 2001 classification system. Statistical analysis was performed with SPSS 18.0 for the Windows program. RESULTS: Our study was conducted with 390 patients with 215 (55%) abnormal Pap smears and 175 (45%) normal Pap smear results. The mean age of the cases was 45.5±9. The prevalence of HPV was 68.8% and the prevalence of abnormal endocervical pathology was 40% in cases with abnormal smear results. The prevalence of HPV positivity in the control group with normal smear was 53.7%. The prevalence of patients with abnormal endocervical sampling results was 2.8%. A significant correlation was found between cervical cytology abnormality and HPV DNA positivity (p=0.002). A significant correlation was found between cervical cytology abnormality and abnormal endocervical sampling results (p˂0.001). As the degree of cervical cytology abnormality increased, it was observed that the frequency of endocervical sample abnormalities and HPV DNA positivity increased (p=0.002). CONCLUSİON: HPV positivity was found to be associated with cervical cytology abnormality. A significant correlation was found between abnormal cervical cytology and abnormal endocervical pathology. As the degree of cervical cytology abnormality increased, it was determined that the frequency of endocervical sample abnormalities and HPV DNA positivity increased.
Keywords:

Abnormal Smear, HPV, Endocervical Sampling, Cervical Cancer,

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Maltepe Tıp Dergisi-Cover
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2009
  • Yayıncı: Maltepe Üniversitesi
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