Sağlıklı Erişkinlerde İstirahat Kalp Hızı Oksidatif Stresle İlişkili Değildir

Giriş: Her ne kadar istirahat kalp hızı (İKH) ve oksidatif stres, kardiyovasküler morbidite ve mortalite için risk faktörleri olsa da bunlar arasındaki ilişki tam olarak anlaşılamamıştır. Bu çalışmamızda, İKH ile oksidatif/ antioksidatif stres belirteçleri arasındaki ilişkiyi araştırmayı amaçladık. Hastalar ve Yöntem: Çalışma 56 sağlıklı gönüllüden (33 erkek; ortalama yaş: 44.1 ± 9.0 yıl) oluşmaktaydı. Gönüllüler kalp hızı çeyrekliklerine göre iki gruba bölündüler: alt iki çeyreklik grup 1 (n= 29) ve üst iki çeyreklik grup 2 (n= 27). Hastaların total oksidan kapasitesi (TOK), total antioksidan kapasitesi (TAK), oksidatif stres indeksi (OSİ) ve serum seruloplasmin düzeylerini ölçük. Bulgular: Bazal klinik karakteristikler ve laboratuvar ölçümleri açısında iki grup arasında önemli bir fark yoktu (p> 0.05 tüm değişkenler için). Ortalama İKH grup 1᾽de 71.3 ± 4.6 iken grup 2᾽de 82.4 ± 4.1 idi. TOK, TAK, OSİ ve seruloplazmin düzeyleri her iki grupta benzerdi (p> 0.05 tüm değişkenler için). İKH ve oksidatif/antioksidatif stres parametreleri arasında anlamlı bir ilişki saptayamadık. Sonuç: Çalışmamızda İKH, TOK, TAK, OSİ ve seruloplazmin düzeyleri ile ilişkili bulunmadı.

Anahtar Kelimeler:

İstirahat kalp hızı, oksidatif stres, total oksidan kapasitesi, total antioksidan kapasitesi, oksidatif stres indeksi, seruloplazmin

Resting Heart Rate is Not Associated with Oxidative Stress in Healthy Adults

Introduction: Although resting heart rate (RHR) and oxidative stress are risk factors for cardiovascular morbidity and mortality, the association between them has not been fully understood. The aim of the present study was to investigate the relationship between RHR and oxidative/antioxidative stress markers. Patients and Methods: The study consisted of 56 healthy volunteers (33 males; mean age: 44.1 ± 9.0 years). Subjects were divided into two groups according to heart rate quartiles: lower two quartiles as group 1 (n= 29) and upper two quartiles as group 2 (n= 27). We measured total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), and ceruloplasmin (CP) levels of subjects. Results: There was no any significant difference in baseline clinical characteristics and laboratory measurements between the groups (p> 0.05 for all variables). Mean RHRs were 71.3 ± 4.6 in group 1 and 82.4 ± 4.1 in group 2. The TAC, TOS, OSI, and CP levels were similar between the two groups (p> 0.05 for all variables). We did not detect any significant association between RHR and oxidative/antioxidative parameters. Conclusion: RHR was not associated with TOS, TAC, OSI, and CP levels in our study.

Keywords:

Resting heart rate, oxidative stress, total oxidant status, total antioxidant status, oxidative stress index, ceruloplasmin,

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi