Monositin HDL Kolesterole Oranının Kardiyak Sendrom X ve Sistemik İnflamasyon ile İlişkisi

Giriş: Bu çalışmanın amacı, kardiyak sendrom X (KSX) hastalarında monositin HDL kolesterole oranı (MHO)’nı ve kolay kullanılabilir inflamatuvar göstericileri araştırmaktır. Hastalar ve Yöntem: Çalışmaya 50’si KSX ve 50’si normal koroner arterlere sahip toplam 100 hasta dahil edilmiştir. Bulgular: Total beyaz küre sayısı, nötrofil sayısı, monosit sayısı, lenfosit sayısı, nötrofil/lenfosit oranı, C-reaktif protein, hsCRP ve MHO KSX grubunda artmıştır (p< 0.05), ancak HDL kolesterol CSX hastalarında kontrol grubuna göre azalmıştır (p< 0.05). Korelasyon analizinde MHO’nun hsCRP (r= 0.375, p< 0.001) ve CRP (r= 0.403, p< 0.001) ile pozitif yönde korelasyon olduğu gösterilmiştir. Multivariate logistic regresyon analizinde MHO’nun KSX hastalığını göstermede bağımsız bir gösterge olduğu bulundu [odds ratio: 1.250, 95% confidence interval (CI): 1.240-1.461, p< 0.001]. Sınır değeri 90.6 alırsak, MHO bu oran ile KSX hastalığının varlığını %78 duyarlılık ve %70 özgüllükle göstermektedir. Sonuç: Çalışmamızda MHO KSX hastalarını göstermede ciddi ve bağımsız bir gösterge olduğu gösterilmiştir.

Anahtar Kelimeler:

Kardiyak sendrom X, monositin HDL kolesterole oranı, inflamatuvar göstergeler

Association of Monocyte-to-HDL Cholesterol Ratio with Cardiac Syndrome X is Linked to Systemic Inflammation

Introduction: The aim of this study was to investigate an easily available inflammatory marker and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) in patients with cardiac syndrome X (CSX). Patients and Methods: The study population included 100 patients of which 50 had CSX (CSX group) and 50 had normal coronary angiograms (control group). Results: Total white blood cell (WBC) count, monocyte count, neutrophil count, NLR, high-sensitivity C-reactive protein (hs-CRP), C-reactive protein (CRP) and MHR were higher in the CSX group (p< 0.05), whereas high-density lipoprotein cholesterol (HDL-C) level was significantly lower in the CSX group as compared with that in the control group (p< 0.05). In the correlation analysis, MHR revealed a significantly positive correlation with hs-CRP (r= 0.375, p< 0.001) and CRP (r= 0.403, p< 0.001). In the multivariate logistic regression analysis, MHR was independently associated with the presence of CSX (odds ratio: 1.250, 95% confidence interval [CI]: 1.240-1.461, p< 0.001). Using a cut-off level of 90.6, pre-procedural MHR predicted the presence of slow coronary flow (SCF) with a sensitivity of 78% and specificity of 70%. Conclusion: In conclusion, our findings revealed that higher MHR levels were significantly and independently associated with the presence of CSX.

Keywords:

Cardiac syndrome X, monocyte-to-HDL cholesterol ratio, inflammatory markers,

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