Ümmühan Nehir SELÇUK, Gökçen ORHAN, Müge TAŞDEMİR METE, Bahar TEMUR, Sevinç BAYER ERDOĞAN, Murat UĞUR, Murat SARGIN, Serap AYKUT ETA

Mitral Kapak Cerrahisinde İloprost Kullanımının Pulmoner Arter Hipertansiyonu Üzerine Klinik Etkisi

Giriş: Mitral kapak cerrahisinde artmış pulmoner arter basıncı artmış mortalite ve morbidite için önemli bir risk faktörüdür. Biz bu çalışmada, prostaglandin analoğu iloprostun, pulmoner arteryel hipertansiyonu (PAH) olan hastalardaki hemodinamik etkilerini araştırdık. Hastalar ve Yöntem: Çalışmamızda hastanemizde 01.01.2003-31.03.2013 tarihleri arasında mitral kapak cerrahisi uygulanan ve PAH nedeniyle intravenöz iloprost tedavisi uygulanan hastalar retrospektif olarak incelendi. Hastaların sistemik ve pulmoner arter basınçları kateter aracılığıyla elde edildi. Elde edilen preoperatif, postoperatif 0. ve 24. saatteki hemodinamik değerler incelendi. Bulgular: Bu periyotta 135 hastaya mitral kapak replasmanı uygulanmış olup, 78 hastaya PAH nedeniyle iloprost tedavisi verilmişti. Hastaların %29.9’u erkek olup hastalar ortalama 54.45 ± 12.48 yaşında idi. Preoperatif değerler ile postoperatif 0 ve 24. saat sistemik ve pulmoner basınçlar karşılaştırıldığında; postoperatif 24. saatte pulmoner arter basıncının ve kan basıncının istatistiksel olarak anlamlı derecede azaldığı görüldü (p

Anahtar Kelimeler:

Mitral kapak cerrahisi, kardiyopulmoner baypas, iloprost, pulmoner hipertansiyon

Clinical Effect of Iloprost on Pulmonary Artery Hypertension After Mitral Valve Surgery

Introduction: Pulmonary arterial hypertension (PAH) is an important risk factor for increased mortality and morbidity during mitral valve surgery. In this study, we analysed the haemodynamic effects of the prostaglandin analogue iloprost in patients with PAH. Patients and Methods: We retrospectively analysed patients with PAH who were undergoing mitral valve surgery and had received intravenous iloprost therapy at our hospital from 1 January 2003 to 31 March 2013. Systemic and pulmonary arterial pressures were measured with catheterisation. The haemodynamic parameters were administered preoperatively and at 0 hours and 24 hours postoperatively. Results: A total of 135 patients had undergone mitral valve operations, of whom 78 patients were administered iloprost during the study period. Of all the cases, 29.9% were male and the average patient age was 54.45 ± 12.48 years. A comparison of the preoperative, hour 0 and hour 24 baseline parameters showed that pulmonary artery pressure and blood pressure statistically significantly decreased at postoperative hour 24 (p

Keywords:

Mitral valve surgery, cardiopulmonary bypass, iloprost, pulmonary hypertension,

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi