Egemen DUYGU, Murat ŞENER, Vedat BAKUY, Abdülkadir Faruk HÖKENEK, Mete GÜRSOY

Inflammation and non-atherosclerotic coronary artery aneurysm

Giriş: Koroner arter anevrizması, genellikle asemptomatik, rastlantısal anjiyografik bir bulgudur. Büyük çoğunluğu ateroskleroza bağlıdır. Bu çalışmada, ateroskleroza bağlı olmayan izole koroner arter anevrizmalarının inflamasyon ile ilişkisini inceledik. Hastalar ve Yöntem: Altı bin sekiz yüz kırk beş koroner anjiyografi verisi geriye dönük olarak incelendi. Toplam 23 hastada 35 koroner arter anevrizması saptandı (%0,34). Hasta takip kartları incelenerek demografik, hematolojik verilere ulaşıldı. Veriler koroner arterleri normal bulunan 23 olgunun sonuçlarıyla kıyaslandı. Bulgular: Nötrofil lenfosit oranı grup 1’de 2,44±0,88, grup II‘de 1,80±0,49 olup, fark anlamlı bulundu (p=0,01). Serum ürik asit seviyesi grup I’de 6,37±1,80 mg/dL olup, grup II’de 4,91±0,99 mg/dL olarak bulundu (p=0,008). Sonuç: Sonuçlarımız, inflamasyon ve oksidatif stresin izole koroner arter anevrizması patogenezinde tetikleyici etkenler olabileceğini işaret etmektedir. Antiinflamatuar ve antioksidan tedavinin koroner arter anevrizması hastalarında yeni bir yaklaşım olabileceği kanaatindeyiz.

Ateroskleroza bağlı olmayan koroner arter anevrizması ve inflamasyon ilişkisi

Introduction: Coronary artery aneurysm is generally presented as an asymptomatic, incidental angiographic finding and is often associated with atherosclerosis. In this study we investigated the relation of non-atherosclerotic isolated coronary artery aneurysm with inflammation. Patients and Methods: Data of 6845 coronary angiography were retrospectively evaluated. A total of 35 non- atherosclerotic isolated coronary artery aneurysms were diagnosed in 23 patients (0.34%). Patients follow-up charts were reviewed, demographic and hematologic parameters were determined and were compared with the results of 23 healthy subjects. Results: Neutrophil to lymphocyte ratio was 2.44±0.88 in group I and 1.80±0.49 in group II, and the difference was found to be significant (p=0.01). Serum uric acid level was 6.37±1.80 mg/dL in group I and 4.91±0.99 in group II, and the difference was significant (p=0.008). Conclusion: Present study indicates two important triggering factors in the pathogenesis of isolated coronary artery aneurysm; inflammation and oxidative stress. Antiinflammatory and antioxidant treatments may be a new approach in patients with coronary artery aneurysm

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi