Zerrin YİĞİT, Cem BOSTAN, Cüneyt KOÇAŞ, Ayşem KAYA, Uğur COŞKUN, Erdem KARACOP, Okay ABACI

Effects of Trimetazidine Treatment on the Lipoprotein-Associated Phospholipase A2 Level and Exercise Parameters in Patients with Stable Angina Pectoris

Giriş: Kararlı anjina pektorisli hastalarda, metabolik bir anti-iskemik ilaç olan trimetazidin (TMZ) tedavisinin risk faktörü olarak kabul edilen lipoprotein ilişkili fosfolipaz A2(Lp-PLA2 ) düzeyi ve egzersiz parametreleri üzerine etkisi araştırıldı. Hastalar ve Yöntem: Egzersiz testi pozitif olan kararlı anjina pektorisli 30 hasta (ort. yaş 62.1 ± 8.3; dağılım 47-77) çalışmaya alındı. Trimetazidin tedavisi öncesinde Lp-PLA2düzeyleri ölçüldü; 12 haftalık TMZ tedavisi sonrasında egzersiz testi ve Lp-PLA2ölçümleri tekrarlandı. Bulgular: Trimetazidin tedavisi sonrasında Lp-PLA2düzeyleri anlamlı düşüş (p= 0.006), egzersiz iş yükü anlamlı artış (p= 0.048) gösterdi. Sonuç: Trimetazidin tedavisi kardiyak metabolizma değişikliği sonucu serbest oksijen radikal oluşumunu ve enfl amasyonu azaltarak Lp-PLA2düzeyinde anlamlı düşüş sağlamaktadır. Bu bulgu, egzersiz parametrelerindeki iyileşmelerle birlikte, TMZ tedavisinin kararlı anjina pektorisli hastaların prognozunda olumlu katkı sağlayabileceğini göstermektedir.

Kararlı Anjina Pektorisli Hastalarda Trimetazidin Tedavisinin Lipoprotein İlişkili Fosfolipaz A2 Düzeyi ve Egzersiz Parametreleri Üzerine Etkisi

Introduction: We examined the clinical effectiveness of trimetazidine (TMZ), a metabolic anti-ischemic agent, on lipoprotein-associated phospholipase A2(Lp-PLA2 ) levels, which is considered a risk factor for cardiovascular events, and on exercise parameters in patients with stable angina pectoris (SAP). Patients and Methods: The study included 30 patients (mean age 62.1 ± 8.3 years; range 47 to 77 years) with SAP and a positive exercise test result. Serum Lp-PLA2levels were measured at baseline. Exercise testing and Lp-PLA2measurements were repeated after at least 12 weeks of TMZ treatment. Results: After TMZ treatment, Lp-PLA2levels decreased signifi cantly (p= 0.006), and workload increased signifi cantly (p= 0.048). Conclusion: Trimetazidine treatment reduces serum Lp-PLA2levels via shifting cardiac metabolism, resulting in decreased production of free oxygen radicals and infl ammation. This fi nding, together with improvements in exercise test parameters, suggests that TMZ may have a benefi cial effect on the prognosis of patients with SAP

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