Ekrem AKSU, Deniz AVCI, Enes ÇELİK, Bayram ÖZTÜRK, Mehmet Buğra BOZAN, Kemal GÖÇER, Ahmet Çağrı AYKAN

COVID-19 Pandemisi Sırasında NSTEMI Hastalarında İnvaziv Tedavi İhtiyacını Belirlemede Yeni Öngörücüler? Geriye Dönük Bir Çalışma

Giriş: Noninvaziv yaklaşım, “Coronavirus Disease-2019 (COVID-19)” pandemisi sırasında akut ST yükselmesiz miyokart infarktüsü-akut koroner sendrom (NSTEMI-AKS) için ilk seçenek haline gelmiştir. Ancak bu hastaların çoğu girişimsel tedaviye ihtiyaç duyar. Bu çalışmada, girişimsel tedaviye ihtiyaç duyan GRACE risk sınıflandırmasına göre orta-yüksek riskli NSTEMI-AKS hastalarını ayırt etmede hematolojik inflamatuvar belirteçlerin olası rolü araştırılmıştır. Hastalar ve Yöntem: Geriye dönük kohort çalışması olarak tasarlanan çalışmaya Ocak 2018-Aralık 2019 tarihleri arasında üçüncü basamak kardiyoloji kliniğinde NSTEMI-AKS tanısı ile koroner anjiyografi yapılan hastalar dahil edilmiştir. AKS hastaları (n= 276), dışlama kriterleri olan hastalar (n= 32) dışındaki sonuçlara göre invaziv tedavi (n= 217) ve medikal tedavi (n= 59) olmak üzere iki gruba ayrılmıştır. Hematolojik inflamatuvar belirteçler gruplar arasında karşılaştırılmıştır. Bulgular: Nötrofil lenfosit oranı (NLR) (EAA: 0.637, %95 CI: 0.563-0.712, p= 0.001) ve sistemik immün inflamasyon indeksi (SII) (EAA: 0.622, %95 CI: 0.545-0.699, p= 0.004) NSTEMI-AKS’de girişimsel tedavi gerekliliğini öngörmüştür. Sonuç: İnvaziv tedavi ihtiyacının bir göstergesi olabilecek NLR ve SII yükselmesinin, NSTEMI-AKS’li hastalarda patofizyolojik sürecin bir nedeni mi yoksa bir sonucu mu olduğu açık değildir. Bununla birlikte,yüksek NLR ve SII değerleri, COVID-19 pandemisi sırasında invaziv tedaviye ihtiyaç duyan NSTEMI-AKS hastalarını ayırt etmeye yardımcı olabilir. Bu çalışmanın sonuçları, NSTEMI-AKS için tedavi stratejisini belirlemede NLR ve SII seviyelerinin ideal kesme noktasını belirlemek için büyük ölçekli çalışmalara olan ihtiyacı göstermektedir.

New Predictors in Determining the Need for Invasive Treatment in NSTEMI During the COVID-19 Pandemic? A Retrospective Study

Introduction: The non-invasive approach has become the first choice for the acute non-ST elevation myocardial infarction-acute coronary syndrome (NSTEMI-ACS) during the Coronavirus Disease-2019 (COVID-19) pandemic. However, most of these patients require interventional treatment. In this study, the possible role of hematological inflammatory markers in differentiating medium-high risk NSTEMI-ACS patients according to the GRACE risk classification in need of interventional treatment was investigated. Patients and Methods: Patients who underwent coronary angiography with the diagnosis of NSTEMI-ACS in a tertiary cardiology clinic between January 2018 and December 2019 were included in the study, which was designed as a retrospective cohort study. NSTEMI-ACS patients (n= 276), except for patients with exclusion criteria (n= 32), were divided into two groups as those in need of invasive treatment (n= 217) and medical treatment (n= 59) according to the results of coronary angiography. The hematological inflammatory markers were compared between groups. Results: Neutrophil to lymphocyte ratio (NLR) (AUC: 0.637, 95% CI: 0.563-0.712, p= 0.001) and systemic immune-inflammation index (SII) (AUC: 0.622, 95% CI: 0.545-0.699, p= 0.004) predicted the requirement of interventional treatment in NSTEMI-ACS. Conclusion: It is unclear whether the NLR and SII elevation, which may be a predictor of the need for invasive treatment, is a cause or a consequence of the pathophysiological process in patients with NSTEMI-ACS. However, elevated NLR and SII values can help distinguish NSTEMI-ACS patients who need invasive treatment during the COVID-19 pandemic. The results of this study, show the need for large-sized studies to determine the ideal cut-off point of NLR and SII levels in determining the treatment strategy for NSTEMI-ACS.

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi