Gonca GÜLBAY, Yasemin KAYA

Obez Hastalarda Vitamin B12 ve Vitamin D’ nin IL-4, IL-10, TNF-Beta ile İlişkisi

Amaç: Obez hastalarda vitamin B12 ve vitamin D nin IL-10, IL-4, TNF-Beta ile ilişkisini incelemeyi amaçladık. Gereç ve Yöntem: Serum IL-10, IL-4 ve TNF-Beta seviyeleri ELISA (Enzyme Linked Immunosorbent Assay) prensibine dayalı kitler kullanılarak ölçülmüştür. Bulgular: IL-10 düzeyi, vitamin D düşük olan grupta anlamlı olarak daha düşük bulunmuştur (p= 0.039). Vitamin B12 normal, vitamin B12 düşük ve kontrol grupları karşılaştırıldığında IL-10 açısından gruplar arasında istatistiksel düzeyde fark bulunmuştur (p=0.002). Post hoc analizi sonucunda IL-10 düzeyi, vitamin B12 düşük grubunda vitamin B12 normal grubuna göre anlamlı olarak daha düşük olarak tespit edilmiştir (0.04). Aynı zamanda vitamin B12 normal grupta (obezite pozitif) kontrol grubuna (non-obez vit B12 normal) göre daha yüksek olarak belirlenmiştir (p=0.001). IL-10 ile vitamin B12 ve Vitamin D arasında korelasyon bakıldığında vitamin B12 ile IL-10 arasında pozitif korelasyon bulundu (r=0.203 p= 0.058). Sonuç: Obez hastalarda vitamin D ve vitamin B12 düşük seviyelerinin IL-10 düzeyinde düşüklüğe neden olduğu gösterilmiştir. Ayrıca obezitenin de IL-10 seviyesinde artışa neden olduğu belirlenmiştir. IL-4 ve TNF-Beta ile vitamin D ve vitamin B12 arasında ilişki bulunamamıştır. Obez hastalarda vitamin B12 ve vitamin D nin IL-4, IL-10, TNF-Beta düzeylerine etkilerini daha iyi görebilmek için daha uzun süreli takip ve daha geniş vaka popülasyonlarında çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

IL-10, IL-4, TNF-beta, Vitamin B12, Vitamin D, Obezite

Relationship of Vitamin B12 and Vitamin D with IL-4, IL-10, TNF Beta in Obese Patients

Objective: We aimed to investigate the relationship of vitamin B12 and vitamin D with IL-4, IL-10 and TNF-Beta in obese patients. Methods: Serum IL-4, IL-10 and TNF-Beta levels were measured using kits based on the enzyme-linked immunosorbent assay (ELISA) principle. Results: The IL-10 level was found to be significantly lower in the low vitamin D group (p= 0.039). When vitamin B12 normal, vitamin B12 low and control groups were compared, a statistical difference was found between the groups in terms of IL-10 (p=0.002). As a result of post hoc analysis, the IL-10 level was found to be significantly lower in the vitamin B12 low group than in the vitamin B12 normal group (0.04). At the same time, vitamin B12 was statistically higher in the normal group (obesity positive) than in the control group (non-obese vit B12 normal) (p=0.001). A positive correlation was found between vitamin B12 and IL-10 (r= 0.203 p= 0.058). Conclusion: It has been shown that low levels of vitamin D and vitamin B12 in obese patients cause low levels of IL-10. It was also found that obesity caused an increase in IL-10 levels. No relationship was found between IL-4 and TNF-Beta and vitamin D and vitamin B12. Longer follow-up and studies in larger case populations are needed to better understand the effects of vitamin B12 and vitamin D on IL-4, IL-10 and TNF-Beta levels in obese patients.

Keywords:

IL-10, IL-4, Obesity, TNF-beta, Vitamin B12, Vitamin D,

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ISSN: 1309-3878
Yayın Aralığı: 3
Başlangıç: 2009
Yayıncı: Düzce Üniversitesi Tıp Fakültesi Aile Hekimliği AD adına Yrd.Doç.Dr.Cemil Işık Sönmez