Distribution of Lymphoid Neoplasms in Northeast Turkey: A retrospective analysis of 1136 Cases According to the World Health Organization Classification

Objective: Malignant lymphoma is one of the most common cancer type around the world. In this study, the distribution and demographic characteristics of the histologic subgroups of mature lymphoid neoplasms in Northeast Turkey were investigated. Methods: The study consists of 1136 patients diagnosed as mature lymphoid neoplasm between 2008 and 2014. The demographic data of the patients were analyzed and histological subgrouping was performed according to the World Health Organization classification. Results: Mature B-cell neoplasms accounted for 79.2% (n=900) of all lymphoid neoplasms, Hodgkin lymphoma (HL) for 10.9% (n=124), mature T/natural killer-cell neoplasms for 9% (n=102), and histiocytic and dendritic cell neoplasms for 0.9% (n=10). In our study, the most common subtypes of lymphoid neoplasms were as follows: diffuse large B-cell lymphoma (n=261; 23%), plasma cell myeloma (n=252; 22.2%), chronic lymphocytic leukemia/small lymphocytic lymphoma (n=230; 20.2%), mycosis fungoides (MF) (n=66; 5.8%) and nodular sclerosing type classical HL (n=63; 5.5%). Only 2.9% of the cases of non-Hodgkin lymphoma (NHL) were follicular lymphoma. All patients with HL were diagnosed by a lymph node biopsy. However, 48.1% of the patients with NHL arose from extranodal sites. Conclusions: This is the first study investigating the distribution of lymphoid neoplasms in Northeast Anatolia region with the review of the literature. The present study showed that the epidemiologic features similar to those reported in Western and Asian countries, whereas some subtypes showed distinct features. The high frequency of MF and the low frequency of follicular lymphoma are interesting findings of this study.

Türkiye’nin Kuzeydoğusundaki Lenfoid Neoplazm Vakalarının Dağılımı: 1136 Vakanın Dünya Sağlık Örgütü Sınıflamasına Göre Retrospektif İncelenmesi

Amaç: Malign lenfoma dünyada en sık görülen kanser tiplerinden biridir. Bu çalışmada, Türkiye’ nin kuzeydoğusundaki matür lenfoid neoplazm vakalarının histolojik alt gruplarının dağılımları ve demografik özellikleri incelenmiştir. Gereç ve Yöntem: Bu çalışmada 2008 ve 2014 yılları arasında matür lenfoid neoplazm tanısı almış 1136 hasta yer almaktadır. Hastaların demografik verileri araştırılıp Dünya Sağlık Örgütü sınıflamasına göre histolojik alt grupları tespit edilmiştir. Bulgular: Tüm lenfoid neoplazilerin %79.2’ si (n=900) matür B hücreli neoplaziler, %10.9’ u (n=124) Hodgkin lenfoma (HL), %9’ u (n=102) matür T/natural killer hücreli neoplaziler, %0.9’ u (n=10) histiyositik ve dendritik hücreli neoplazilerden oluşmaktadır. Çalışmamızda lenfoid neoplazilerin en sık görülen alt tipleri şöyledir: diffüz büyük B hücreli lenfoma (n=261; %23), plazma hücreli miyelom (n=252; %22.2), kronik lenfositik lösemi/ küçük lenfositik lenfoma (n=230; %20.2), mikozis fungoides (MF) (n=66; %5.8) ve nodular sklerozan tip HL (n=63; %5.5). Non-Hodgkin lymphoma (NHL) tanılı vakaların yalnızca %2.9’ u folliküler lenfoma tanılıdır. HL hastalarının tümü lenf nodu biyopsisinden tanı almıştır. Bununla birlikte NHL vakalarının %48.1’ i ekstranodal bölge yerleşimlidir. Sonuç: Bu çalışma Kuzeydoğu Anadolu’ daki lenfoid neoplazilerin dağılımını literatür verileriyle karşılaştırarak inceleyen ilk çalışma niteliğindedir. Çalışmamızda batı ve Asya ülkeleri ile benzer epidemiyolojik veriler elde edilmesine rağmen bazı alt gruplarda farklılıklar dikkati çekmektedir. MF’ in sıklıkla görülmesi ve folliküler lenfomanın nadir izlenmesi bu çalışmanın çarpıcı bulgularıdır.

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ISSN: 1309-3878
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2009
Yayıncı: Düzce Üniversitesi Tıp Fakültesi Aile Hekimliği AD adına Yrd.Doç.Dr.Cemil Işık Sönmez