Metilparabenin Drosophila melanogaster’in Gelişimi ve Fekunditesi Üzerine Etkileri

Parabenler; gıdalar, kozmetik ürünler ve ilaçlar gibi birçok endüstriyel üründe koruyucu olarak kullanılan bir kimyasal madde grubudur. Son yıllarda yapılan çalışmalar, bu kimyasalların endokrin bozucu özelliği olduğunu ortaya koymuştur. Drosophila melanogaster çeşitli kimyasalların toksik etkisini in vivo olarak test etmek için kullanılan uygun model organizmalardan biridir. Bu çalışmada, en sık kullanılan parabenlerden biri olan metilparabenin (MP) (50 mM, 100 mM ve 200 mM) D. melanogaster'in gelişimi ve fekunditesi üzerine etkileri incelenmiştir. Pupalaşma ve erginleşme yüzdelerinde anlamlı bir fark gözlenmemiştir. Fakat MP uygulaması pupalaşma ve erginleşme sürelerinde gecikmeye yol açmıştır (p<0.05). MP ortalama yavru döl sayısında anlamlı bir değişime yol açmazken, tüm dozlarda fekunditeyi önemli ölçüde azaltmıştır (p<0.05).

Anahtar Kelimeler:

Paraben, , endokrin bozucular, endokrin bozucular, endokrin bozucular, gelişim zamanı gecikmesi, yavru döl sayısı, yumurta sayısı

The Effect of Methylparaben on Development and Fecundity of Drosophila melanogaster

Parabens are a group of chemicals used as preservatives in many industrial products such as foods, cosmetics, and pharmaceuticals. Recent studies have revealed that these chemicals have endocrine disrupting properties. Drosophila melanogaster is one of the suitable model organisms used to test the toxic effect of various chemicals in vivo. In this study, the effects of methylparaben (MP) (50 mM, 100 mM, and 200 mM), one of the most commonly used parabens, on the developmental parameters and fecundity of D. melanogaster were examined. No significant difference was observed in the viability rates from larva to pupa and from pupa to adult. However, experimented MP concentrations caused a delay in larva to pupa and pupa to adult developmental times (p<0.05). While MP did not cause a significant change in mean offspring number, it significantly decreased fecundity at all doses (p<0.05).

Keywords:

Paraben, endocrine disrupting compounds, developmental delay, offspring number, egg number,

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