Onur BASBUG, Uğur AYDOĞDU, Zahid Tevfik AĞAOĞLU

Parvoviral Enteritisli Köpeklerde Prognostik Parametreler Olarak C-Reaktif Protein, Albümin, Neopterin, Ürokinaz Tipi Plazminojen Aktivatör Reseptörü ve Lökosit Seviyelerinin Değerlendirilmesi

Bu çalışmanın amacı, parvoviral enteritisli köpeklerde C-reaktif protein (CRP), albumin, neopterin (Np), ürokinaz tipi plazminojen aktivatör reseptörü (uPAR) ve lökosit seviyelerindeki değişiklikleri belirlemek ve bunların prognostik önemini göstermekti. Çalışmada 40’ı parvoviral enteritisli ve 8’i sağlıklı olmak üzere toplam 48 köpek kullanıldı. Parvoviral enteritisli köpekler ölen (n=12) ve hayatta kalanlar (n=28) olarak iki gruba ayrıldı. Çalışmada ölen parvoviral enteritisli köpeklerin lökosit seviyesi kontrol grubu ve yaşayan parvoviral enteritisli köpeklere göre önemli düzeyde (p<0.05) düşük bulundu. Ölen parvoviral enteritisli köpeklerin serum albümin konsantrasyonları da kontrol grubundan önemli düzeyde (p<0.05) düşük bulundu. Aksine, ölen ve yaşayan parvoviral enteritisli köpeklerin CRP düzeyi kontrol grubuna göre önemli düzeyde (p<0.05) yüksek olarak tespit edildi. Np ve uPAR düzeyleri açısından ise gruplar arasında istatistiksel olarak anlamlı fark yoktu. Lökosit, CRP ve albüminin cut-off değerleri sırasıyla 4.5×109L, 120.50 mg/L ve 2.28 g/dL olarak tespit edildi. Sonuç olarak, parvoviral enteritisli köpeklerde azalmış lökosit ve albumin seviyeleri ile artmış CRP seviyelerinin kötü prognozun bir göstergesi olabileceği ifade edilebilir. Ayrıca serum Np ve uPAR düzeylerinin parvoviral enteritisli köpeklerde prognostik bir öneme sahip olmadığı belirlenmiştir.

Anahtar Kelimeler:

Parvoviral enteritis, C-reactive protein, neopterin, ürokinaz plazminojen aktivatör reseptör, köpek

Evaluation of C-Reactive Protein, Albumin, Neopterin, Urokinase Type Plasminogen Activator Receptor and Leukocyte Levels as Prognostic Parameters in Dogs with Parvoviral Enteritis

The aim of this study was to determine the changes in C-reactive protein (CRP), albumin, neopterin (Np), urokinase type plasminogen activator receptor (uPAR) and leukocyte levels in dogs with parvoviral enteritis and to show the prognostic importance of these. In the study, a total of 48 dogs, 40 with parvoviral enteritis and 8 were healthy, were used. The dogs with parvoviral enteritis were divided into two subgroups, non-surviving (n=12) and surviving (n=28). The non-surviving dogs with parvoviral enteritis in the study had significantly (p<0.05) lower leukocyte levels than the control group and the surviving dogs with parvoviral enteritis. Serum albumin concentrations of non-surviving dogs with parvoviral enteritis were also significantly (p<0.05) lower than the control group. On the contrary, the CRP levels of the non-surviving and surviving dogs with parvoviral enteritis were significantly (p<0.05) higher than the control group. There was also no statistically significant difference between the groups in terms of Np and uPAR levels. The cut-off values of leukocyte, CRP and albumin were 4.5×109L, 120.50 mg/L and 2.28 g/dL, respectively. As a result, it can be stated that decreased leukocyte and albumin levels and increased CRP levels in dogs with parvoviral enteritis may be an indicator of poor prognosis. It was also determined that serum Np and uPAR levels in dogs with parvoviral enteritis do not have any prognostic importance.

Keywords:

Parvoviral enteritis, C-reaktive protein, neopterin, urokinase type plasminogen activator receptor, dog,

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