Kronik enteropatili kedilerde bağırsak mikrobiyota analizleri ile kısa dönem rektal enema probiyotik sağaltımı

Bağırsak mikrobiyotasındaki bir dengesizlik, kedilerdeki kronik enteropatide olduğu gibi gastrointestinal sistemdeki kronik inflamasyon oluşumu için hazırlayıcı bir faktör olarak hizmet ettiği tespit edilmiştir. Probiyotik uygulamasının gastrointestinal rahatsızlıkları azaltabileceği varsayımı göz önüne alındığında, ülkemizde kronik enteropatili kedilerde rektal yoldan etkileri hiç araştırılmamıştır. Bu nedenle bu çalışmanın amacı, kedilerde Bifidobacterium kombinasyonu [Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium animalis], Lactobacillus suşları [Lactobacillus rhamnosus, Lactobacillus gastrikus, Lactobacillus acidophilus], Bacillus suşları [Bacillus clausii, Bacillus subtilis] ve yeni nesil bir probiyotik Akkermansia muciniphilia'yı içeren çok zincirli bir probiyotik tedavisinin terapötik etkinliğini kedilerde rektal yoldan (enema) değerlendirmektir. Teşhis, a) klinik, b) hematolojik ve serum biyokimyasal analizlerinin yanı sıra Feline Kronik Enteropati Aktivite İndeksi'ne (FCEAI) göre puanlamaya dayanıyordu. Her kedi muayene edildi ve analiz edildi/yeniden değerlendirildi ve 10 günlük indüksiyon dönemi için tedavinin başlangıcında ve sonunda bir FCEAI puanı verildi. Rektal lavman probiyotik tedavisi, yorumlamaya tabi tutulmuş kompozit FCEAI skoru (p<0.01) ve laboratuvar parametreleri yeniden değerlendirme değerleri (p<0.01) anlamlı derecede azalmıştır. Herhangi bir yan etkisi olmayan bu tedavi yöntemi, tekrarlayan ve dejeneratif etkileri olan diğer ilgili tedavi yöntemlerinin yerini almalıdır.

Anahtar Kelimeler:

disbiyoz, ; Gİ inflamasyon, mikrobiyom analizi, probiyoterapi

Short-Term Rectal Enema Probiotic Treatment with Intestinal Microbiota Analysis in Cats with Chronic Enteropathy

An imbalance in gut microbiota detected to serve as a predisposing factor for existence of chronic inflammation of the gastrointestinal tract, such as chronic enteropathy among cats. Given the postulation that probiotic administration might mitigate gastrointestinal disorders, its effects via rectal route have never been explored in our country among cats with chronic enteropathy. Thus the purpose of the present study was to evaluate the therapeutical efficacy of an multiple chain probiotic treatment involving Bifidobacterium combination [Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium animalis], Lactobacillus strains [Lactobacillus rhamnosus, Lactobacillus gastricus, Lactobacillus acidophilus, Lactobacillus plantarum], Bacillus strains [Bacillus clausii, Bacillus subtilis] and a next generation probiotic Akkermansia muciniphilia via rectal route (enema)in cats with cEnT. Diagnosis was based on a) clinical, b) hematological and serum biochemical analysis along with scoring to those of Feline Chronic Enteropathy Activity Index (FCEAI). Each cat was inspected and analyzed/reevaluated and assigned a FCEAI score at the start and end of treatment for 10 day induction period. Rectal enema probiotic treatment resulted with significantly decreased composite FCEAI score (p<0.01) and laboratory parameters re-evaluation values (p<0.01) subjected to interpretation. This treatment modality without any side effects, should be subtitute other relevant treatment modalities with relapsing and degenerative effects.

Keywords:

dysbiosis, GI inflammation, Microbiome analysis, Probiotheraphy,

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