Ümide DEMİR ÖZKAY, Umut İrfan ÜÇEL, Nazlı TURAN YÜCEL, Özgür Devrim CAN

Benzotiyazol Halkası Taşıyan Bazı Bileşiklerin Antinosiseptif ve Anksiyolitik-Benzeri Etkileri

Bu çalışmanın amacı benzotiyazol halkası taşıyan bazı bileşiklerin antinosiseptif ve anksiyolitik-benzeri etkilerinin incelenmesidir. 40 mg/kg dozda uygulanan test bileşiklerinin antinosiseptif etkileri kuyruk sıkıştırma, sıcak plaka ve asetik asid ile indüklenen kıvranma testleri ile araştırılmıştır. Bileşiklerin anksiyolitik-benzeri etkilerini incelemek için delikli tahta ve yükseltilmiş artı labirent testleri gerçekleştirilmiştir. Farelerin motor koordinasyonlarını değerlendirmek üzere Rota-rod cihazı kullanılmıştır. Deneyler sonucunda 3f, 3g ve 3h kodlu bileşiklerin kuyruk sıkıştırma ve sıcak plaka testlerinde hayvanların reaksiyon sürelerini artırdığı ve 3e kodlu bileşiğin ise asetik asid ile indüklenen kıvranma testinde farelerin kıvranma sayılarını azalttığı belirlenmiştir. Diğer yandan, 3f, 3g ve 3h kodlu bileşikler delikli tahta testinde farelerin ilk baş daldırma sürelerini kısaltırken toplam baş daldırma sayılarını artırmıştır. Yükseltilmiş artı labirent testinde ise aynı türevlerin farelerin açık kola giriş sayılarının ve açık kolda kalma sürelerinin yüzdelerini artırdığı ortaya konulmuştur. Rota-rod testlerinde test bileşikleri farelerin dönen milden düşme sürelerini değiştirmemiştir. Tüm bu bulgular, 3f, 3g ve 3h kodlu bileşiklerin santral antinosiseptif ve anksiyolitik-benzeri etki gösterdiklerine; 3e kodlu bileşiğin ise periferal antinosiseptif etki gösterdiğine işaret etmektedir.

Anahtar Kelimeler:

Benzotiyazol halkası, antinosiseptif, anksiyolitik, Rota-rod

Antinociceptive and Anxiolytic-Like Effects of Some Compounds Carrying Benzothiazole Ring

The aim of this study was to examine the antinociceptive and anxiolytic-like effects of some compounds carrying benzothiazole ring. The antinociceptive effects of test compounds, administrated at a dose of 40 mg/kg, were investigated by tail clip, hot plate and acetic acid-induced writhing tests. Hole board and elevated plus maze tests were performed to evaluate the anxiolytic-like effects of the compounds. Rota-rod device was used to assess the motor coordinations of mice. As a result of the experiments, it was determined that compounds 3f, 3g and 3h increased the reaction times of animals in the tail clip and hot plate tests, and compound 3e reduced the writhing number of mice in the acetic acid-induced writhing test. On the other hand, in the hole board test, compounds 3f, 3g and 3h reduced the first head-dipping latencies of mice while increasing the total number of head-dips. In the elevated plus maze test, it has been shown that the same derivatives increase the percentages of open arm entries and time spent in the open arms. In the Rota-rod tests, test compounds did not change the falling time of mice from the rotating mill. All these findings point out that compounds 3f, 3g and 3h exhibit central antinociceptive and anxiolytic-like effects and compound 3e shows a peripheral antinociceptive effect.

Keywords:

Benzothiazole ring, antinociceptive, anxiolytic, Rota-rod,

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