AYÇA İNCİ, Melahat ÇOBAN, Metin SARIKAYA, Ümmühan MADEN

PREDİYALİZ KRONİK BÖBREK HASTALARINDA KESİTSEL BİR ÇALIŞMA: YAŞAM KALİTESİ VE ETKİLEYEN FAKTÖRLER

AMAÇ: Kronik Böbrek Hastalığı (KBH) insidansı ve prevalansı tüm dünyada artmaktadır. KBH’da sıklıkla komplikasyonlar fazladır ve kötü yaşam kalitesi ile birliktedir. Bu çalışmanın amacı Kısa form-36 (SF-36) ölçeği ile KBH’da yaşam kalitesinin değerlendirilmesi ve böbrek fonksiyonları, yaş, cinsiyet, eğitim düzeyi, sosyo ekonomik durum, hemoglobin, albumin, HBA1c, 25OHvitamin D düzeyinin yaşam kalitesi üzerindeki etkisinin araştırılmasıdır.

Anahtar Kelimeler:

Kronik Böbrek Hastalığı, SF-36, yaşam kalitesi

A CROSS-SECTIONAL STUDY IN PATIENTS WITH PRE-DIALYSIS CHRONIC KIDNEY DISEASE: QUALITY OF LIFE AND RELATED FACTORS

OBJECTIVE: The incidence and prevalence of patients with chronic kidney disease (CKD) is increasing worldwide. It is often associated with a high prevalence of complications and worse quality of life. The main objective of this study is to evaluate quality of life (QOL) using the generic instrument short form-36 (SF-36) in patients with CKD and identify the possible influence of the degree of renal function, age, gender, education level, socioeconomic status, hemoglobin, albumin, HbA1c and 25 hydroxy vitamin D level on QOL. MATERIALS AND METHODS: For this cross-sectional study, we included 211 CKD patients ( median age 56 ± 13 years) admitted to the outpatient clinic of Antalya Research and Training Hospital Nephrology Unit between January and June 2016. Participants completed the short form-36 health survey (SF-36). Laboratory tests and clinical and demographic data were obtained. RESULTS: The patients were classified into CKD stages according to the CKD-EPI equation: 59,2% were in CKD Stage 1-3 and 40,8% were in Stage 4-5. The patients in Stage 4-5 had lower scores in physical aspects. Age influence QOL negatively. CKD patients with higher hemoglobin, albumin and 25 hydroxy vitamin D levels has better functional capacity and physical aspects. High HbA1c levels significantly associated with bad functional capacity. Education level and socioeconomic status is associated with QOL. CONCLUSIONS: Renal function, age, gender, education level and socioeconomic status influenced QOL. To imrove QOL in CKD patients we need to focus on factors that can be changed, such as improving the hemoglobin, albumin, HbA1c and 25 hydroxy vitamin D levels.

Keywords:

Chronic Kidney Disease SF-36, , quality of life,

PDF

___

Andrew S. Levey, Josef Coresh, National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2-1):S1–266.
Süleymanlar G, Utaş C, Arinsoy T ,et al.A population-based survey of Chronic REnal Disease In Turkey--the CREDIT study. Nephrol Dial Transplant. 2011 Jun;26(6):1862-71.
Perlman RL, Finkelstein FO, Liu L, et al. Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute CKD study. Am J Kidney Dis. 2005;45:658–66.
Harris LE, Luft FC, Rudy DW, Tierney WM. Clinical correlates of functional status in patients with chronic renal insufficiency. AmJ Kidney Dis. 1993;21:161–6.
Sesso R, Yoshihiro MM. Time of diagnosis of chronic renal failure and assessment of quality of life in hemodialysis patients. Nephrol Dial Transplant. 1997;12:2111–16.
Koçyiğit H, Aydemir Ö, Fişek G, Ölmez N, Memiş A: Kısa form- 36 (KF-36)’nın türkçe versiyonunun güvenilirliği. İlaç ve Tedavi Dergisi 1999;12:102-106
Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150:604-12.
Ware JE, Jr., Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30:473–83.
Conde´ SA, Fernandes N, Santos FR, Chouab A, Mota MM, Bastos MG. Cognitive decline, depression and quality of life in patients at different stages of chronic kidney disease. J Bras Nefrol. 2010;32:242–8.
Boini S, Frimat L, Kessler M, Briançon S, Thilly N. Predialysis therapeutic care and health-related quality of life at dialysis onset (The pharmacoepidemiologic AVENIR study). Health Qual Life Outcomes. 2011;9:7.
Kusek JW, Greene P, Wang S-R, et al. Crosssectional study of health-related quality of life in african americanswith chronic renal insufficiency: the african american study of kidney disease and hypertension trial. Am J Kidney Dis. 2002;39(3):513–24.
Chow FY, Briganti EM, Kerr PG, et al. Health-related quality of life in australian adults with renal insufficiency: a populationbased study. Am J Kidney Dis. 2003;41(3):596–604.
Cruz MC, Andrade C, Urrutia M, Draibe S, Nogueira-Martins LA, de Castro Cintra Sesso R. Quality of life in patients with chronic kidney disease. Clinics. 2011;66(6):991–5.
Alexander M, Kewalramani R, Agodoa I, Globe D. Association of anemia correction with health related quality of life in patients not on dialysis. Curr Med Res Opin. 2007;23(12):2997–3008.
Akizawa T, Gejyo F, Nishi S, et al. Positive outcomes of high hemoglobin target in patients with chronic kidney disease not on dialysis: a randomized controlled study. Ther Apher Dial. 2011;15(5):431–40.
Mittal SK, Aherm L, Flaster E, Maesaka JK and Fishbane S. Selfassessed physical and mental functional of hemodialysis patients. Nephrol Dial Transplant. 2001;16:1387 94.
Migardi G, The DIA-QOL Group: From the development to the clinical application of a questionnaire on the quality of life in dialysis. The experience of the Italian Collaborative DIA-QOL (Dialysis-Quality of Life) Group. Nephrol Dial Transplant,1998; 13: 70-75.
Chao YS1, Ekwaru JP, Ohinmaa A, Griener G, Veugelers PJ. Vitamin D and health-related quality of life in a community sample of older Canadians. Qual Life Res. 2014 Nov;23(9):2569- 75.
Tavallaii SA1, Einollahi B, Azizabadi Farahani M, Namdari M.Socioeconomic links to health-related quality of life, anxiety, and depression in kidney transplant recipients.Iran J Kidney Dis. 2009 Jan;3(1):40-4.
Lew SQ, Patel SS. Psychosocial and quality of life issues in women with end-stage renal disease. Adv Chronic Kidney Dis. 2007;14(4):358–63.