Fatma Dilek DELLAL, Mutlu NİYAZOĞLU, Esra HATIPOGLU, Fatma AKSOY, Halime ÜNVER, Esranur ADEMOĞLU, Yalçın ARAL

KRONİK OTOİMMÜN TİROİDİT VE NESFATİN-1 DÜZEYİ ARASINDAKİ İLİŞKİ

AMAÇ: Bu çalışmanın amacı kronik tiroiditli hastalarda nesfatin-1 düzeyi ile tiroid otoimmünitesi arasındaki ilişkiyi değerlendirmektir.GEREÇ VE YÖNTEM: Hashimoto tiroiditli 49 premenopozal kadın ve yaş ve vücut kitle indeksi (VKI) uyumlu 23 sağlıklı kadın, bu kesitsel karşılaştırmalı çalışmaya dahil edildi. Plazma nesfatin-1, açlık ve tokluk glukoz, hemoglobin A1c (HbA1c), açlık insülin, kolesterol parametreleri, serbest tiroksin (ST4), serbest T3 (ST3), tirotropin (TSH), anti-tiroid peroksidaz antikor (anti-TPO) and anti-tiroglobin (anti-TG) antikor değerleri için kan örnekleri alındı. Ek olarak tüm vakalarda, insülin direnci için homeostatik model değerlendirmesi (HOMA-İR) ve vücut kitle indeksi (VKİ) hesaplandı ve bel/kalça oranı ölçüldü.BULGULAR: Hashimoto tiroiditli hastaların ortalama yaşı 35,5±8,1, kontrol grubunun ise 33,2±7,1 idi (p=0.324). VKI ve bel/kalça oranı, gruplar arasında benzerdi (p=0.239 ve p=0.317). TSH, anti-TPO ve anti-TG düzeyleri hasta grubunda anlamlı derecede yüksekti (p=0.023, p<0.001 ve p<0.001). Hastalarda trigliserid düzeyleri istatistiksel anlamlılık sınırında daha yüksekti(p=0.05). Her iki grup arasında nesfatin düzeyleri açısından istatistiksel anlamlı farklılık yoktu [0,4 (0,39-0,43), 0,39 (0,39-0,39) ng/ml;p=0.329].SONUÇ: Kronik otoimmün tiroiditte tiroid hormon değişiklikleri ya da otoimmünite, nesfatin-1 düzeylerinde değişikliğe yol açmayabilir. Hashimoto tiroiditli hastalardaki tokluk ve enerji tüketiminden nesfatin-1 dışındaki mekanizmalar sorumlu olabilir.

Anahtar Kelimeler:

Hashimoto tiroiditi, Kronik otoimmün tiroidit, Nesfatin, Tiroid stimulan hormon, Tiroid otoantikor

ASSOCIATION BETWEEN CHRONIC AUTOIMMUNE THYROIDITIS AND NESFATIN-1 LEVELS

OBJECTIVE: The aim of this study was to evaluate relationship between nesfatin-1 levels and thyroid autoimmunity in cases with chronic thyroiditis.MATERIAL AND METHODS: A total of 49 consecutive premenopausal women with Hashimoto’s thyroiditis and, age and body mass index (BMI)-matched 23 healthy female subjects were included in this cross-sectional comparative study. Levels of nesfatin-1, fasting and postprandial blood glucose, hemoglobin A1c (HbA1c), fasting insulin, cholesterol, free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH), anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) were obtained for all cases. Additionally homeostatic model assessment for insulin resistance (HOMA-IR) and BMI was calculated and waist-to-hip ratio (WHR) was measured for each case.RESULTS: The mean age of the group with Hashimoto’s thyroiditis was 35.5±8.1 years and of the healthy controls was 33.2±7.1 years old (p=0.324). BMI and WHR were similar between the groups (p=0.239 and p=0.317). TSH, anti-TPO and anti-TG levels were significantly higher in cases with Hashimoto’s thyroiditis (p=0.023, p<0.001 and p<0.001). Triglyceride levels were higher in the patients with Hashimoto’s thyroiditis at the limit of statistical significance (p=0.05). Nesfatin levels were not different statistically in between two groups [0.4 (0.39-0.43) , 0.39 (0.39-0.39) ng/ml;p=0.329].CONCLUSIONS: Alterations in thyroid hormones or autoimmunity in chronic autoimmune thyroditis may not alter nesfatin-1 levels. Different mechanisms, other than nesfatin-1, may be responsible for changes in satiety and energy expenditure in Hashimoto’s thyroiditis.

Keywords:

Hashimoto’s thyroditis, Chronic autoimmune thyroditis, Nesfatin, Thyroid stimulating hormone, Thyroid autoantibody.,

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