Karaciğer Kan Akımının Yaşa Göre Değişiminin Doppler Ultrasonografik Değerlendirilmesi

Çalışmamızda karaciğer kan akımının ve karaciğer Doppler parametrelerinin yaşlanmayla değişimini değerlendirmeyi amaçladık. Yaşları 26-67 arasında değişen 30 sağlıklı (16 erkek ve 14 kadın) gönüllüde renkli Doppler ultrasonografi ile noninvazif olarak hepatik arter ve portal ven kan akım hacimleri ile bunların aritmetik toplamı olarak karaciğer kan akım hacmi ölçüldü. Ölçümler sırasında hepatik arter rezistif ve pulsatilite indeksleri ile portal venin pulsatilite indeksleri ve maksimum hızları da ölçülerek elde edilen bütün değerlerin yaşla korelasyonu incelendi. Hepatik arter, portal ven ve toplam karaciğer kan akımları yaşla anlamlı negatif korelasyon gösterdiler. Sonuç olarak yaşla karaciğer kan akımının azaldığı bulundu ve karaciğer hastalıklarının Doppler ile tanı ve takiplerinde bu azalmanın göz önünde bulundurulması gerekliliği ifade edildi

Karaciğer Kan Akımının Yaşa Göre Değişiminin Doppler Ultrasonografik Değerlendirilmesi

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  • Ternberg JL, Butcher HR. Blood-flow relation between hepatic artery and portal vein. Science, 1965; 150:1030-1031.
  • Price JB Jr, Voorhee AB Jr, Britton RC. Operative hemodynamic studies in portal hypertension: significance and limitations. Arch Surg, 1967; 95:843-851.
  • Bookstein J, Boijsen E, Olin T, Vang J. Angiography after end-to-side portacaval shunt: clinical, laboratory, and pharmacoangiographic observations. Invest Radiol, 1971; 6:101-109.
  • Reynolds TB. The role of hemodynamic measurements in portosystemic shunt surgery. Arch Surg, 1974; 108:276-281.
  • Reuter SR, Berk RN, Orloff T. Angiographic study of the pre- and postoperative hemodynamics in patients with side-to-side portacaval shunts. Radiology, 1975; 116:33-39.
  • Burgener FA, Gutierrez OH, Logsdon GA. Angiographic, hemodynamic, and histologic evaluation of portal hypertension and periportal fibrosis induced in the dog by intraportal polyvinyl alcohol injections. Radiology, 1982 ;143:379-385.
  • Itai Y, Moss AA, Goldberg HI. Transient hepatic attenuation difference of lobar or segmental distribution detected by dynamic computed tomography. Radiology, 1982; 14:835-839.
  • Matsui O, Takashima T, Kadoya K, et al. Segmental staining on hepatic arteriography as a sign of intrahepatic portal vein obstruction. Radiology, 1984; 152:601-606.
  • Vestal RE, Wood AJJ, Branch RJ et al. Studies of drug disposition in the elderly using model compounds. In: Kitani K ed. Liver and Aging. Amsterdam: Elsevier, 1978: 343-55.
  • Seifalian AM, Stansby GP, Hobbs KE, Hawkes DJ, Colchester AC. Measurement of liver blood flow: a review. HPB Surg, 1991; 4(3):171-86.
  • Haktanir A, Cihan BS, Celenk C, Cihan S. Value of Doppler sonography in assessing the progression of chronic viral hepatitis and in the diagnosis and grading of cirrhosis. J Ultrasound Med, 2005; 24(3):311-21.
  • Zoli M, Magalotti D, Bianchi G, et al. Functional hepatic flow and Doppler-assessed total hepatic flow in control subjects and in patients with cirrhosis. J Hepatol, 1995; 23:129-134.
  • Ohnishi K, Saito M, Nakayama T, et al. Portal venous hemodynamics in chronic liver disease: effect of posture change and exercise. Radiology, 1985; 155: 757-761.
  • Zironi G, Gaiani S, Fenyves D, Rigamonti A, Bolomdi L, Barnara L. Value of measurement of mean portal flow velocity by Doppler flowmetry in the diagnosis of portal hypertension. J Hepatol, 1992; 16:298-303.
  • Koda M, Murawaki Y, Kawasaki H, Ikawa S. Portal blood velocity and portal blood flow in patients with chronic viral hepatitis: relation to histological liver fibrosis. Hepatogastroenterology, 1996; 43:199-202.
  • Piscaglia F, Gaiani S, Calderoni D, et al. Influence of liver fibrosis on hepatic artery Doppler resistance index in chronic hepatitis of viral origin. Scand J Gastroenterol, 2001; 36:647-652.
  • Colli A, Cocciolo M, Riva C, et al. Abnormalities of Doppler waveform of the hepatic veins in patients with chronic liver disease: correlation with histologic findings. AJR Am J Roentgenol, 1994; 162:833-837.
  • Zoli M, Magalotti D, Bianchi G, et al. Total and functional hepatic blood flow decrease in parallel with ageing. Age Ageing, 1999; 28:29-33.
  • Tai DI, Chuah SK, Chen CL, Lo SK, Changchien CS, Li IT. Inter-observer variability of portal hemodynamics measured by Doppler ultrasound on three different locations of portal vein. J Clin Ultrasound, 1996; 24:61-66.
  • Port S, Cobb FR, Coleman RE, Jones RH. Effect of age on the response of the left ventricular ejection fraction to exercise. N Engl J Med, 1980; 13;303:1133-1137.
  • Marchesini G, Bua V, Brunori A, et al. Galactose elimination capacity and liver volume in aging man. Hepatology, 1988; 8:1079-1083.
  • Howell TH. Organ weights in nonagenarians. J Am Geriatr Soc, 1978 ; 26:385-390.
  • Kenichi K. Aging and the liver. In: Popper H, Schaff- ner E (Editörler). Progress in Liver Diseases, vol. 8. Orlando, FL: Grune & Stratton, 1986; 602-623.
  • Popper H. Aging and the liver. In: Popper H, Schaff- ner E (Editörler). Progress in Liver Diseases, vol. 8. Orlando, FL: Grune & Stratton, 1986; 659-683.