Göknur KALKAN, Zennure TAKCI, Özlem TEKİN

Hidroksiüre'nin Neden Olduğu Longitidunal Melanonişi

Hidroksiüre, miyeloproliferatif hastalıkların tedavisinde kullanılan sitostatik bir kemoterapotik bir ajandır. Uzun dönem tedavide mukokütanöz yan etkiler ve tırnak pigmentasyonu görülebilmektedir. Hidroxiürenin indüklediği melanonişi, en çok kadınlarda en sık olarak da longitidunal çizgilenme şeklinde görülür. Burada polisitemia rubra vera tanısıyla hidroksiüre kullanan, tedavisinin 18. ayında el parmak tırnaklarında longitudinal melanonişi ortaya çıkan 65 yaşında kadın hasta sunulmuştur. Bu vakadan hareketle, miyeloproliferatif hastalıklarda ve orak hücreli aneminin tedavisinde kullanımı gittikçe yaygınlaşan hidroksiürenin çok sayıdaki kutanöz yan etkilerinin farkında olunması amaçlanmıştır

Anahtar Kelimeler:

Hidroksiüre, melanonişi, polisitemi vera

Hidroksiüre'nin Neden Olduğu Longitidunal Melanonişi

Hydroxyurea is a chemotherapeutic agent which is used in the management of myeloproliferative disorders. Mucocutaneous adverse effects and nail hyperpigmentation can be observed in long-term treatment. Cases of hydroxyurea-induced melanonychia develop predominantly in female patients and the most common pattern is longitudinal bands. Here we present a case of 65-year-old woman patient that has longitudinal melanonychia on the nails of the hands, observed at the eighteenth month of the treatment of hydroxyurea. By means of this case, it is aimed to be aware of the cutaneous side effects of hydroxyurea which is commonly used in myeloproliferative disorders

Keywords:

Hydroxyurea; melanonychia, polycythemia vera,

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