Türkan Paşalı KİLİT, Kevser ONBAŞI, Gül Sena TOPAL, Filiz ÖZYİĞİT

CİDDİ HİPERKALSEMİ İLE PREZENTE OLAN PARATİROİD ADENOMU VE PARATİROİD KARSİNOMA OLGUSU

Hiperkalsemi kemikler, gastrointestinal sistem veya böbreklerden hücre dışı sıvıya geçen kalsiyum miktarı, plazmadan uzaklaştırılan kalsiyum miktarından fazla olması olarak tanımlanan patolojik bir durumdur. Primer hiperparatiroidizm ve malign hastalıklara bağlı hiperkalsemi, tüm hiperkalsemi olgularının %90’ından fazlasını oluşturmaktadır. Hastanede yatışı gerektirecek ciddiyette hastalığı olanlarda en sık hiperkalsemi nedeni malignite, poliklinik hastalarında ise primer hiperparatiroididir. Serum kalsiyum düzeyi 15 mg/dl'nin üzerinde olan veya semptomatik hiperkalsemisi olan hastaların acil tedavisi gereklidir. Paratiroid karsinomu çok ender görülen bir endokrin tümör olup, primer hiperparatiroidizm olgularının %1’inden daha azını oluşturur. Önemli ölçüde yükselmiş serum kalsiyum ve parathormon düzeyleri, palpe edilebilir bir paratiroid bezi olması ve ağır semptomların olması durumunda paratiroid karsinomundan şüphelenilebilir. Bu olgu sunumunda ciddi hiperkalsemiye bağlı semptomlarla başvuran, paratiroid adenomu ve paratiroid karsinomunun birlikte görüldüğü primer hiperparatiroidili bir vakayı sunduk

Anahtar Kelimeler:

Paratiroid karsinoma, , Hiperkalsemi, , Primer hiperparatiroidizm

A CASE OF PARATHYROID ADENOMA AND PARATHYROID CARCINOMA PRESENTING WITH SEVERE HYPERCALCEMIA

Hypercalcemia is a pathological condition characterized by the amount of calcium passing through the extracellular fluid from the bones, the gastrointestinal tract, or the kidneys, which is greater than the amount of calcium removed from the plasma. Hypercalcemia due to primary hyperparathyroidism and malign diseases constitutes more than 90% of all hypercalcemia cases. The most frequent cause of hypercalcemia is malignancy in patients with serious illness that should be hospitalized, and primary hyperparathyroidism in outpatients. Urgent treatment is required for patients with a serum calcium level above 15 mg/dl or with symptomatic hypercalcemia. Parathyroid carcinoma is a very rare endocrine composing, with less than 1% of primary hyperparathyroidism cases. Parathyroid carcinoma can be suspected in cases of significantly high serum calcium and parathormone levels, a palpable parathyroid gland, and severe symptoms. In this case report, we presented a case of primary hyperparathyroidism with parathyroid adenoma and parathyroid carcinoma, which was presented with symptoms due to severe hypercalcemia.

Keywords:

Hypercalcemia, Primary hyperparathyroidism, Parathyroid adenoma, Parathyroid carcinoma,

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