Fatih Kar, Ahmet Musmul, Hakan Şentürk, Selma Yılmaz

COVID-19 İlişkili Biyokimyasal ve Hematolojik Parametreler: Tek merkezli Popülasyon İndeks Çalışması

Amaç: COVID-19’un karaciğer ve böbrek fonksiyon testleri, elektrolit düzeyleri ve inflamatuar belirteçler gibi biyokimyasal ve hematolojik parametreler üzerindeki etkilerinin incelenmesini amaçladık. Yöntem: Araştırma 01.03.2020-01.10.2020 tarihleri arasında Eskişehir Şehir Hastanesine başvuran COVID-19 test sonucu pozitif ve negatif olan 10269 hasta üzerinde gerçekleştirildi. Dahil edilen hastaların COVID-19 tanıları gerçek zamanlı polimeraz zincir reaksiyonu ve bilgisayarlı tomografi akciğer taraması ile yapıldı. COVID-19 pozitif ve negatif test sonucuna sahip iki grubun numunelerinde biyokimyasal parametreler incelendi. Ayrıca hematolojik parametreler retrospektif olarak elde edildi. Bulgular: BASO%, EOS#, EOS%, HCT, HGB, LYM#, LYM%, MCHC, MCV, MONO#, MONO%, MPV, NEU#, NEU%, PCT ve PLT değerlerinde gruplar arasında istatistiksel fark vardı (p<0,05). BASO# ve MCH parametrelerinde ise istatistiksel fark tespit edilmedi. Değerler incelendiğinde; COVID-19 pozitif hastalarındaki BASO%, EOS%, HCT, LYM#, LYM%, MCHC, MONO%, NEU%, PCT ve RBC parametreleri COVID-19 negatif hastalara göre daha yüksekti. Diğer parametreler ise pozitif hastalarda negatif hastalara göre daha düşüktü (p<0,05). Potasyum ve prokalsitonin parametreleri haricindeki tüm biyokimya test sonuçlarında gruplar arasında istatistiksel olarak fark tespit edildi (p<0,05). COVID-19 pozitif hastalarından elde edilen ALP, ALT, AST, Direkt Bilirubin, Total Bilirubin, BUN, CRP, D-Dimer, Ferritin, GGT, Kreatinin, LDH ve Troponin verileri negatif hastalara göre daha yüksekti. Albümin, Klor, Demir, Sodyum ve total protein düzeyleri ise pozitif hastalarda negatif hastalara göre daha düşüktü (p<0,05). Sonuç: COVID-19 pozitif hastalarda, çoklu organ işlev bozukluğunu gösterebilecek biyokimyasal değişkenler bulundu. Karaciğer ve böbrek fonksiyon testleri gibi bazı biyokimyasal indekslerdeki anormallikler, hastalığın şiddetini bir dereceye kadar yansıtabilir. Bu kapsamlı biyokimyasal ve hematolojik göstergeler, hastalığın klinik yönetiminde dikkate alınarak indeks ve panel oluşturmada kullanılabilir.

Anahtar Kelimeler:

COVID-19, SARS-CoV-2, Hematolojik parametreler, biyokimyasal biyobelirteçler

COVID-19-Related Biochemical and Hematological Parameters: A Single-Center Population Index Study

Objective: We aimed to examine the effects of COVID-19 on biochemical and hematological parameters such as liver and kidney function tests, electrolyte levels and inflammatory markers. Methods: The research was carried out on 10269 patients who applied to Eskişehir City Hospital between 01.03.2020 and 01.10.2020 with positive and negative COVID-19 test results. Included patients were diagnosed with COVID-19 by real-time polymerase chain reaction and computed tomography Biochemical parameters were examined in the samples of two groups with positive and negative COVID-19 test results. In addition, hematological parameters were obtained retrospectively. Results: BASO%, EOS#, EOS%, HCT, HGB, LYM#, LYM%, MCHC, MCV, MONO#, MONO%, MPV, NEU#, NEU%, PCT and PLT (p<0.05). There was no statistical difference in BASO# and MCH parameters. BASO%, EOS%, HCT, LYM#, LYM%, MCHC, MONO%, NEU%, PCT and RBC parameters in COVID-19 positive patients were higher than in COVID-19 negative patients. Other parameters were lower in positive patients than in negative patients (p<0.05). There was a statistical difference between the groups in all biochemistry test results except potassium and procalcitonin parameters (p<0.05). ALP, ALT, AST, Direct Bilirubin, Total Bilirubin, BUN, CRP, D-Dimer, Ferritin, GGT, Creatinine, LDH and Troponin data obtained from COVID-19 positive patients were higher than control group. Albumin, Chlorine, Iron, Sodium and total protein levels were lower in positive patients than in negative patients (p<0.05). Conclusion: Biochemical variants found in COVID-19 positive patients that may indicate multi-organ dysfunction. Abnormalities in some biochemical indices, such as liver and kidney function tests, may reflect the severity of the disease to some degree. These comprehensive biochemical and hematological indicators can be used to create indexes and panels, taking into account the clinical management of the disease.

Keywords:

COVID-19, SARS-CoV-2, Hematological parameters, Biochemical biomarkers,

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Dünya Sağlık Örgütü: Coronavirus (COVID-19) Dashboard. Erişim: https://covid19.who.int (Erişim tarihi: 10.07.2021)
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