Can ilker Demir, Çiğdem Vural, Umay Kiraz, Esra Civriz

Lumbosakral Bölgenin Subkutan Dokusunda Benign Granüler Hücreli Tümör: Olgu Sunumu

Granüler hücreli tümörler (GHT), nöral/schwann hücrelerinden köken alan sıklıkla benign, çok nadir görülen yumuşak doku tümörleri olup en sık deri ve baş-boyun bölgesinden kaynaklanırlar. Fanburg-Smith kriterlerine göre benign, atipik ve malign olarak sınıflandırılan bu tümörler genellikle asemptomatik olup, genellikle 3 cm’in altında, tek bir lezyon şeklinde ve iyi sınırlı kitleler oluştururlar. Ayırıcı tanıda çok sayıda tümörün ve reaktif durumların düşünülmesi gerekmektedir. Biz burada 48 yaşındaki kadın hastada izlenen, lumbosakral bölgede deri altında lokalize olan bir benign granüler hücreli tümörün histopatolojik özellikleri ile ayırıcı tanısını literatür eşliğinde sunduk.

Benign Granular Cell Tumor in The Subcutaneous Tissue of The Lumbosacral Region: A Case Report

Granular cell tumors (GCT) are often benign, very rare soft tissue neoplasms originating from neural / schwanian cells, most often located from the skin and head and neck region. These tumors, which are classified as benign, atypical and malignant according to Fanburg-Smith criteria, are generally asymptomatic and usually form solitary, well-demarcated masses below 3 cm. Numerous tumors and reactive conditions need to be considered in differential diagnosis. Here, we presented the differential diagnosis and histopathological features of a benign granular cell tumor localized subcutaneous in the lumbosacral region, which was observed in a 48-year-old female patient.

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1.Mnasri H, Bouchoucha S. Granular cell tumour of the perianal region: Which therapeutic attitude. Acta Chir. Belg. 2005;105(1):112–113.
2.Qureshi NA, Tahir M, Carmichael AR. Granular cell tumour of the soft tissues: A case report and literature review. Int. Semin. Surg. Oncol. 2006;3.
3.Machado I, Cruz J, Lavernia J, ve ark. Solitary, multiple, benign, atypical, or malignant: the “Granular Cell Tumor” puzzle. Virchows Arch. 2016;468(5):527–538.
4.Mobarki M, Dumollard JM, Dal Col P, Camy F, Peoc'h M, Karpathiou G. Granular cell tumor a study of 42 cases and systemic review of the literature. Pathol. Res. Pract. 2020;216(4).
5.Liu Y, Zheng Q, Wang C, Wang J, Ming J, Zhang Y, et all. Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break-apart FISH in 45 cases. Oncol. Lett. 2019;18(6):6355–6360.
6.Aoyama K, Kamio T, Hirano A, Seshimo A, Kameoka S. Granular cell tumors: a report of six cases. World J. Surg. Oncol. 2012;10:1–6.
7.Moten AS, Movva S, Mehren M von, Wu H, Esnaola NF, Reddy SS, et all. Granular cell tumor experience at a comprehensive cancer center. J. Surg. Res. 2018;226:1–7.
8.Gross VL, Lynfield Y. Multiple cutaneous granular cell tumors: A case report and review of the literature. Cutis. 2002;69(5):343–346.
9.Bozdağ Kaplan N, Dursun İH, Dikilitaş M,Harputluoğlu H, Yılmaz E, Şahin N. Vulvanın nadir görülen granüler hücreli tümörü: Olgu sunumu. Turk Onkol. Derg. 2015;30(2):78–81.
10. Goetz A, Nweze N, Joshi A, Farma J. Synchronous subcutaneous granular celltumours, a rare presentation. Ann. R. Coll. Surg. Engl. 2018;100(4):e85–e87.
11. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue. Diagnostic criteria and clinicopathologic correlation. Am. J. Surg. Pathol. 1998;22(7):779–794.
12.Kesici U, Mataracı E, Kesici S, Sezgin Z. Granular cell tumor on perianal region: A case report. Acta Med. Iran. 2013;51(7):509–511.