Çiğdem ÖZER, Dilek KUZEY, Bahriye SIRAV ARAL, Fatih ŞENTÜRK

Hipertansif Ve Hipertansif Olmayan Sıçanlarda 2100 MHz Radyo Frekans Radyasyonun Testis Dokusunda Oksidan Stres Üzerine Etkisi

GİRİŞ veAMAÇ: Günümüzde ilerleyen teknoloji ile birlikte daha fazla radyasyona maruz kalmaktayız. Radyasyon maruziyetinin biyolojik sistemlerdeki etkilerini inceleyen çok sayıda çalışma olmasına rağmen hipertansiflerdeki etkilerini inceleyen çalışma bulunmamaktadır. Bu çalışmada hipertansif ve hipertansif olmayan sıçanların testis dokusunda 2100 MHz RFR nin oksidatif strese etkilerini incelemeyi amaçladık. YÖNTEM ve GEREÇLER: 24 adet, erkek Wistar Albino sıçan 4 gruba ayrıldı; 1) Kontrol (K), 2) Kontrol+Hipertansiyon (K+H), 3) Radyasyon (R), 4) Radyasyon+Hipertansiyon (R+H). Sıçanlarda hipertansiyonu indüklemek için 1 ay süre ile 1 ml çeşme suyunda çözünen 60 mg/kg L-NAME oral gavaj ile verildi. Sıçanlar 2100 MHz RFR’ye günde 60 dakika/5 gün/8 hafta boyunca maruz bırakıldı. Uygulamaların bitiminde sıçanlar anestezi altında dekapite edilerek testis dokusunda göstergesi malondialdehit (MDA), Nitrit+nitrat (NOx) ve glutatyon (GSH) düzeyleri çalışıldı. Sonuçlar One-way ANOVA followed by post hoc Tukey tests ile karşılaştırıldı. p

Effect of 2100 MHz Radio Frequency Radiation on Oxidative Stress on Testicular Tissue of Hypertensive and Non-Hypertensive Rats

INTRODUCTION: Nowadays exposure to radiation has been increasing with the advancement of technology. Although considerable research hasfocused on the effects of radiation exposure on biological systems, its effect on hypertensives has previously never been addressed. In this study, the effect of 2100 MHz radio frequency radiation (RFR) on oxidative stress on testicular tissue of hypertensive and non-hypertensive rats is aimed to be investigated. METHODS: Twenty-four male Wistar Albino rats were allocated into four groups: 1) Control (C), 2) Control+Hypertension (C+H), 3) Radiation (R), 4) Hypertension+ Radiation (H+R). In order to induce hypertension in rats. 60 mg/kg L-NAME dissolved in 1 ml tap water was orally administered to rats for one month. Rats were exposed to 2100 MHz RFR for 60 min /day, 5 days/ week for 8 weeks. Following the experiments, the rats were decapitated under anesthesia and malondialdehyde (MDA), Nitrite+nitrate (NOx) and glutathione (GSH) levels were examined on testicular tissue. Results were compared with One-way ANOVA followed by post hoc Tukey tests. Values of p

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