Aktif Epilepsili Hastaların Klinik ve Demografik Profili: Türkiye'deki Bir Üçüncü Basamak Hastanesinin Deneyimleri

ÖZGİRİŞ ve AMAÇ: Üçüncü basamak bir hastanede epilepsi polikliniğine başvuran hastaların klinik ve demografik bulgularını araştırmak.YÖNTEM ve GEREÇLER: Ocak 2016 - Şubat 2018 tarihleri arasında epilepsi polikliniğine başvuran aktif epilepsili 187 hasta retrospektif olarak incelendi. Demografik özelliklerin yanı sıra; nöbet sıklığı, hastalık süresi, nöbet tipi, antiepileptikler, elektroensefalografik (EEG) ve manyetik rezonans görüntüleme (MRG) bulguları kaydedildi.BULGULAR: Hastaların yaş ortalaması 36,9 ± 13,1; ve % 54,5'i erkekti. Ailede epilepsi öyküsü 48 hastada (% 25.7) bulundu. 35 hastada (% 18.7) ebeveynler arasında akrabalık vardı. En sık görülen risk faktörleri kafa travması, febril konvülsiyon ve perinatal problemler idi. Fokal nöbetler % 67.9, jeneralize nöbetler% 29.3, sınıflandırılamayan nöbetler% 2.7 idi. 107 hastanın (% 57.2) beyin MR'ı ve 57 hastanın (% 30.5) interiktal EEG'si normaldi. Hastaların toplam 116'sı (% 62) monoterapi alırken, 71'i (% 38) polyterapiye almaktaydı.TARTIŞMA ve SONUÇ: Bu çalışmada, hastaların klinik ve demografik verileri literatür ile uyumlu idi. Kapsamlı epilepsi kliniklerinde düzenli takip ile yapılan ayrıntılı muayenenin nöbetlerin önlenmesinde ve daha iyi sonuç alınmasında potansiyel bir fayda sağlayacağına inanıyoruz.

Clinical and Demographic Profile of Patients with Active Epilepsy: Experience From a Tertiary Care Hospital in Turkey

ABSTRACTINTRODUCTION: To investigate the clinical and demographic findings of patients at epilepsy outpatient clinic of a tertiary care hospital.METHODS: We retrospectively analysed one hundred and eighty-seven patients with active epilepsy who admitted to our epilepsy clinic between January 2016 and February 2018. In addition to demographic characteristics, we evaluated clinical variables such as; seizure frequency, duration of illness, type of seizures, antiepileptics, electroencephalographic (EEG) and magnetic resonance imaging (MRI) findings.RESULTS: The mean age of the patients were 36,9 ± 13,1 years; and 54.5% were male. Family history of epilepsy was found in 48 patients (25.7%), and 35 patients (18.7%) had a kinship between parents. The most frequent risk factors werehead trauma, febrile convulsions and perinatal problems. Partial seizures was seen in 67.9 %, generalised seizures in 29.3% and unclassified seizures in 2.7%. Brain MRI of 107 patients (57.2%) and interictal EEG of 57 patients (30.5%) was normal. A total of 116 (62%) received monotherapy, while 71 (38%) continued on polytherapy.DISCUSSION AND CONCLUSION: In this study, clinical and demographic data of the patients were consistent with the literature. We believe that detailed examination with regular follow- up in comprehensive epilepsy clinics would provide a potential benefit in preventing seizures and better outcome

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