ÖTİROİD HASHİMOTO TİROİDİTLİ ÇOCUK VE ADÖLESANLARDA BİR İNFLAMASYON BELİRTECİ OLARAK NÖTROFİL/LENFOSİT VE PLATELET/LENFOSİT ORANLARI
Amaç: Hashimoto tiroiditi, tiroit bezine karşı oluşmuş antikorlar aracılığıyla gelişen kronik inflamatuvar bir hastalıktır. Nötrofil/lenfosit oranı ve platelet/lenfosit oranı inflamasyonu göstermede kullanılan parametrelerdir. Bu çalışmada ötiroid Hashimoto tiroiditli çocuk ve adölesanlarda nötrofil/lenfosit oranı ve platelet/lenfosit oranı kullanılarak sistemik inflamasyonun değerlendirilmesi planlandı.
Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios as an Inflammation Marker in Children and Adolescents with Euthyroid Hashimoto Thyroiditis
Objective: Hashimoto thyroiditis is a chronic inflammatory disease caused by antibodies against the thyroid gland. Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio are parameters used to show inflammation. In this study, it was planned to evaluate systemic inflammation using neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in children and adolescents with euthyroid Hashimoto thyroiditis.
___
- 1. Mincer DL, Jialal I. Hashimoto Thyroiditis. Treasure Island (FL). StatPearls Publishing, 2021.
- 1. Mincer DL, Jialal I. Hashimoto Thyroiditis. Treasure Island (FL). StatPearls Publishing, 2021.
- 2. Penta L, Cofini M, Lanciotti L, Leonardi A, Principi N, Esposito S. Hashimoto's disease and thyroid cancer in children: are they associated? Front Endocrinol (Lausanne). 2018;9:565.
- 2. Penta L, Cofini M, Lanciotti L, Leonardi A, Principi N, Esposito S. Hashimoto's disease and thyroid cancer in children: are they associated? Front Endocrinol (Lausanne). 2018;9:565.
- 3. Rajamanickam R, Shanmugavelu L, Subramanian S, Prasad HK, Krishnamoorthy N. Hashimoto's thyroiditis in South Indian Centre. Indian J Pediatr. 2016;83(11):1227-31.
- 3. Rajamanickam R, Shanmugavelu L, Subramanian S, Prasad HK, Krishnamoorthy N. Hashimoto's thyroiditis in South Indian Centre. Indian J Pediatr. 2016;83(11):1227-31.
- 4. Yilmaz H, Ucan B, Sayki M, Unsal I, Sahin M, Ozbek M et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015;9(4):299-304.
- 4. Yilmaz H, Ucan B, Sayki M, Unsal I, Sahin M, Ozbek M et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015;9(4):299-304.
- 5. Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A, Gurel A et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015;8(7):11420-7.
- 5. Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A, Gurel A et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015;8(7):11420-7.
- 6. Aydin M, Yilmaz A, Donma MM, Tulubas F, Demirkol M, Erdogan M et al. Neutrophil/lymphocyte ratio in obese adolescents. Northern Clinics of İstanbul. 2015;2(2):87-91.
- 6. Aydin M, Yilmaz A, Donma MM, Tulubas F, Demirkol M, Erdogan M et al. Neutrophil/lymphocyte ratio in obese adolescents. Northern Clinics of İstanbul. 2015;2(2):87-91.
- 7. Azak E, Uçaktürk SA, Çetin İ, Gürsu HA, Mengen E, Pamuk U. Subclinical myocardial dysfunction demonstrated by speckle tracking echocardiography in children with euthyroid Hashimoto’s thyroiditis. J Clin Res Pediatr Endocrinol. 2019;11(4):410-8.
- 7. Azak E, Uçaktürk SA, Çetin İ, Gürsu HA, Mengen E, Pamuk U. Subclinical myocardial dysfunction demonstrated by speckle tracking echocardiography in children with euthyroid Hashimoto’s thyroiditis. J Clin Res Pediatr Endocrinol. 2019;11(4):410-8.
- 8. Yetkin DO, Dogantekin B. The lipid parameters and lipoprotein (A) excess in Hashimoto thyroiditis. Int J Endocrinol. 2015;2015:952729.
- 8. Yetkin DO, Dogantekin B. The lipid parameters and lipoprotein (A) excess in Hashimoto thyroiditis. Int J Endocrinol. 2015;2015:952729.
- 9. Vatan MB, Varım C, Ağaç MT, Varım P, Çakar MA, Aksoy M et al. Echocardiographic evaluation of biventricular function in patients with euthyroid Hashimoto's thyroiditis. Med Princ Pract. 2016;25(2):143-9.
- 9. Vatan MB, Varım C, Ağaç MT, Varım P, Çakar MA, Aksoy M et al. Echocardiographic evaluation of biventricular function in patients with euthyroid Hashimoto's thyroiditis. Med Princ Pract. 2016;25(2):143-9.
- 10. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014;13(4-5):391-7.
11. Akamizu T, Amino N. Hashimoto’s thyroiditis. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dungan K et al., eds. Endotext. South Dartmouth (MA). MDText.com, Inc, 2000.
- 12. Weetman AP. An update on the pathogenesis of Hashimoto's thyroiditis. J Endocrinol Invest. 2021;44(5):883-90.
- 12. Weetman AP. An update on the pathogenesis of Hashimoto's thyroiditis. J Endocrinol Invest. 2021;44(5):883-90.
- 13. Elsherbiny TM. Thyroid autoimmunity is associated with hypothyroid-like symptoms compared with nonautoimmune benign thyroid diseases using a thyroid-specific questionnaire. The Egyptian Journal of Internal Medicine. 2019;31(4):683-8.
- 13. Elsherbiny TM. Thyroid autoimmunity is associated with hypothyroid-like symptoms compared with nonautoimmune benign thyroid diseases using a thyroid-specific questionnaire. The Egyptian Journal of Internal Medicine. 2019;31(4):683-8.
- 14. Baser H, Can U, Baser S, Yerlikaya FH, Aslan U, Hidayetoglu BT. Assessment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis. Endocrine. 2015;48(3):916-23.
- 14. Baser H, Can U, Baser S, Yerlikaya FH, Aslan U, Hidayetoglu BT. Assessment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis. Endocrine. 2015;48(3):916-23.
- 15. Shimada H, Takiguchi N, Kainuma O, Soda H, Ikeda A, Cho A et al. High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. Gastric Cancer. 2010;13(3):170-6.
- 15. Shimada H, Takiguchi N, Kainuma O, Soda H, Ikeda A, Cho A et al. High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. Gastric Cancer. 2010;13(3):170-6.
- 16. Jung JY, Lee E, Suh CH, Kim HA. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are associated with disease activity in polymyalgia rheumatica. J Clin Lab Anal. 2019;33(9):e23000.
- 16. Jung JY, Lee E, Suh CH, Kim HA. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are associated with disease activity in polymyalgia rheumatica. J Clin Lab Anal. 2019;33(9):e23000.
- 17. Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26(3):372-6.
- 17. Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26(3):372-6.
- 18. Acarturk G, Acay A, Demir K, Ulu MS, Ahsen A, Yuksel S. Neutrophil-to-lymphocyte ratio in inflammatory bowel disease - as a new predictor of disease severity. Bratisl Lek Listy. 2015;116(4):213-7.
- 19. Ozmen S, Timur O, Calik I, Altinkaynak K, Simsek E, Gozcu H et al. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer. Endocr Regul. 2017;51(3):131-6.
- 19. Ozmen S, Timur O, Calik I, Altinkaynak K, Simsek E, Gozcu H et al. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer. Endocr Regul. 2017;51(3):131-6.
- 20. Cengiz H, Varim C, Demirci T, Cetin S. Hemogram parameters in the patients with subacute thyroiditis. Pak J Med Sci. 2020;36(2):240-5.
- 20. Cengiz H, Varim C, Demirci T, Cetin S. Hemogram parameters in the patients with subacute thyroiditis. Pak J Med Sci. 2020;36(2):240-5.
- 21. Aktas G, Sit M, Dikbas O, Erkol H, Altinordu R, Erkus E et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto's thyroiditis. Rev Assoc Med Bras (1992). 2017;63(12):1065-8.
- 21. Aktas G, Sit M, Dikbas O, Erkol H, Altinordu R, Erkus E et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto's thyroiditis. Rev Assoc Med Bras (1992). 2017;63(12):1065-8.
- 22. Bilge M, Yesilova A, Adas M, Helvaci A. Neutrophil- and platelet- to lymphocyte ratio in patients with euthyroid Hashimoto's thyroiditis. Exp Clin Endocrinol Diabetes. 2019;127(8):545-9.
- 22. Bilge M, Yesilova A, Adas M, Helvaci A. Neutrophil- and platelet- to lymphocyte ratio in patients with euthyroid Hashimoto's thyroiditis. Exp Clin Endocrinol Diabetes. 2019;127(8):545-9.
- 23. Onalan E, Dönder E. Neutrophil and platelet to lymphocyte ratio in patients with hypothyroid Hashimoto's thyroiditis. Acta Biomed. 2020;91(2):310-4.
- 23. Onalan E, Dönder E. Neutrophil and platelet to lymphocyte ratio in patients with hypothyroid Hashimoto's thyroiditis. Acta Biomed. 2020;91(2):310-4.
- 24. Fawzy RM, Said EA, Mansour AI. Association of neutrophil to lymphocyte ratio with disease activity indices and musculoskeletal ultrasound findings in recent onset rheumatoid arthritis patients. The Egyptian Rheumatologist. 2017;39(4):203-6.
- 25. Guclu F, Ozmen B, Kirmaz C, Kafesciler SO, Degirmenci PB, Taneli F et al. Down-regulation of the auto-aggressive processes in patients with hypothyroid Hashimoto's thyroiditis following substitutive treatment with L-thyroxine. Eur Cytokine Netw. 2009;20(1):27-32.
- 25. Guclu F, Ozmen B, Kirmaz C, Kafesciler SO, Degirmenci PB, Taneli F et al. Down-regulation of the auto-aggressive processes in patients with hypothyroid Hashimoto's thyroiditis following substitutive treatment with L-thyroxine. Eur Cytokine Netw. 2009;20(1):27-32.
- 26. Stuijver DJ, Elbers LP, van Zaane B, Dekkers OM, Spek CA, Gerdes VE, et al. The effect of levothyroxine on expression of inflammation-related genes in healthy subjects: a controlled randomized crossover study. Horm Metab Res. 2014;46(11):789-93.
- 26. Stuijver DJ, Elbers LP, van Zaane B, Dekkers OM, Spek CA, Gerdes VE, et al. The effect of levothyroxine on expression of inflammation-related genes in healthy subjects: a controlled randomized crossover study. Horm Metab Res. 2014;46(11):789-93.
- 27. Bavarsad K, Saadat S, Mohammadian Roshan N, Hadjzadeh MA, Boskabady MH. Effects of levothyroxine on lung inflammation, oxidative stress and pathology in a rat model of Alzheimer's disease. Respir Physiol Neurobiol. 2020;277:103437.
- 27. Bavarsad K, Saadat S, Mohammadian Roshan N, Hadjzadeh MA, Boskabady MH. Effects of levothyroxine on lung inflammation, oxidative stress and pathology in a rat model of Alzheimer's disease. Respir Physiol Neurobiol. 2020;277:103437.
- 28. Kratzsch J, Fiedler GM, Leichtle A, Brügel M, Buchbinder S, Otto L et al. New reference intervals for thyrotropin and thyroid hormones based on National Academy of Clinical Biochemistry criteria and regular ultrasonography of the thyroid. Clin Chem. 2005;51(8):1480-6.
- 28. Kratzsch J, Fiedler GM, Leichtle A, Brügel M, Buchbinder S, Otto L et al. New reference intervals for thyrotropin and thyroid hormones based on National Academy of Clinical Biochemistry criteria and regular ultrasonography of the thyroid. Clin Chem. 2005;51(8):1480-6.
- 29. Bektas Uysal H, Ayhan M. Autoimmunity affects health-related quality of life in patients with Hashimoto's thyroiditis. Kaohsiung J Med Sci. 2016;32(8):427-33.
- 29. Bektas Uysal H, Ayhan M. Autoimmunity affects health-related quality of life in patients with Hashimoto's thyroiditis. Kaohsiung J Med Sci. 2016;32(8):427-33.