Ersin DEMİR

1410

Streptozotosinin Neden Olduğu Tip-1 Diyabette Çam Yağının Karaciğer ve Böbrek Dokusundaki Bazı Biyokimyasal Parametrelere Etkisi

Bu çalışma tip-1 diyabet oluşturulan sıçanlarda, çam yağının hiperglisemi, MDA-TBA, glutatyon, doku total protein, ADEK vitaminleri ve kolesterol üzerine etkilerinin araştırılması için tasarlandı. Sıçanlar kontrol K , diyabet STZ-DM ve diyabet+çam STZ-DM+ÇY yağı olmak üzere üç grubu ayrıldı. Diyabet gruplarına intraperitoneal enjeksiyonla streptozotosin 65 mg/kg verilerek diyabet oluşturuldu. Çam yağı grubundaki sıçanlara STZ-DM+ÇY haftada iki gün 1 ml/kg v/v dozunda intraperitoneal enjeksiyonla çam yağı ve ayrıca 0.5 ml çam yağı 500 ml içme suyuna ilave edilerek verildi. Diyabet grubu ile karşılaştırıldığında, STZ-DM+ÇY grubunda, postprandial kan glikoz düzeyinin anlamlı bir şekilde azaldığı p
Anahtar Kelimeler:

Çam yağı, Hiperglisemi, Lipid peroksidasyon, ADEK vitamin, Kolesterol, Glutatyon

The Effects of Pine Oil on Some Biochemical Parameters in the Liver and Kidney Streptozotocin Induced Tip-1 Diabetes

The present study was designed to evaluate the effect of pine oil on hyperglycemia and MDA-TBA, glutathione, tissue total protein, ADEK vitamins and cholesterol parameters in streptozotocin-induced type-1 diabetic rats. Rats were divided into three groups: control C diabetes STZ-DM , diabetes+pine oil STZ-DM+PO grups. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin 65 mg/kg . 1 ml/kg the dose pine oil was intraperitoneally injected twice in a week to the diabetes+pine oil STZ-DM+PO , and additionally 0.5 ml /500 ml dose of pine oil was added to drinking water of these group. Postprandial blood glucose levels decrease signifi cantly p
Keywords:

Pine oil, Hyperglycemia, Lipid peroxidation, Vitamin ADEK, Cholesterol, Glutathione,

PDF

___

  • Ahn, TH., Yang, YS., Lee, JC., Moon, CJ., Kim, SH., Jun, W., Park, SC., Kim, JC. 2007. Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats. Phytother. Res., 21: 1015–1019.
  • Arulselvan, P., Subramanian, S.P. 2007. Benefi cial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic β-cells in experimental diabetes in rats. Chemico-Biol. Interact., 165: 155–164.
  • Aydin, B., Unsal, M., Sekeroglu, ZA., Gülbahar, Y. 2011. The antioxidant and antigenotoxic effects of Pycnogenol® on rats treated with cisplatin. Biol. Trace. Elem. Res., 142: 638–650.
  • Basu, T.K., Basualdo, C. 1997. Vitamin A homeostasis and diabetes mellitus. Nutrition, 13(9): 804-806.
  • Baydas, G., Canatan, H., Türkoglu, A. 2002. Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus. J. Pineal Res., 32: 225-230.
  • Baytop, T., 2001. Therapy with Medicinal Plants in Turkey (Past and Present), 1st ed. Istanbul University, Istanbul, 178–249.
  • Bragagnolo, N., Rodriguez-Amaya, DB. 2003. Comparison of the cholesterol content of Brazilian chicken and quail eggs. J. Food Comp. Anal., 16: 147-153.
  • Brigelius-Flohè, R., Traber, M.G. 1999. Vitamin E: function and metabolism. FASEB J. 13: 1145–1155.
  • Cao, U., Dc, E., In, U., Ac, N. 2006. Effect of glycaemic control on serum retinol and beta carotene levels in Type 2 diabetics in Calabar, Nigeria. Mal. J. Nutr., 12(1): 55-65.
  • Cemek, M., Kağa, S., Simşek, N., Büyükokuroğlu, M.E., Konuk, M. 2008. Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin- induced diabetic rats. J. Natural Med., 62(3): 284-293.
  • Chandra, A., Mahdi, A.A., Ahmad, S., Singh, R.K. 2007. Indian herbs result in hypoglycemic responses in streptozotocin- induced diabetic rats. Nutr. Res., 27: 161-168.
  • Clark, SP., Bollag, WB., Westlund, KN., Ma, F., Falls, G., Xie, D., Johnson, M., Isales, CM., Bhattacharyya, MH. 2013. Pine oil effects on chemical and thermal Injury in mice and cultured mouse dorsal root ganglion neurons. Phytother. Res., DOI: 10.1002/ptr.4991.
  • Dembinska-Kiec, A., Mykkänen, O., Kiec-Wilk, B., Mykkänen, H. 2008. Antioxidant phytochemicals against type 2 diabetes. Brit. J. Nutr., 99, E-Suppl. 1: 109-117.
  • Demir, E., Yilmaz, O., Ozsahin, A.D. 2013. The effect of some biochemical parameters in brain tissue of rats pine oil streptozotocin with experimental diabetes in rats. Int. J. Diabet. Res., 2(3): 39-44.
  • Pietta, PG. 2000. Flavonoids as antioxidants. J. Nat. Prod., 63(7): 1035-1042.
  • Prasath, GS., Subramanian, SP. 2013. Fisetin, a tetra hydroxy fl avone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats. Food Chem. Toxicol., 59: 249-255.
  • Raja, AB., Elanchezhiyan, C., Sethupathy, S. 2010. Antihyperlipidemic activity of Helicteres isora fruit extract on streptozotocin induced diabetic male wistar rats. Eur. Rev. Med.Pharmacol. Sci., 14: 191-196.
  • Ramachandran, V., Saravanan, R. 2013. Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes. J. Funct. Food., 5: 1077-1087.
  • Ramesh, B., Viswanathan, P., Pugalendi, K.V. 2007. Protective effect of Umbelliferone on membranous fatty acid composition in streptozotocin-induced diabetic rats. Eur. J. Pharmacol., 566: 231-239.
  • Saini, S., Sharma, S. 2013. Antidiabetic effect of Helianthus annuus L., seeds ethanolic extract in streptozotocin- nicotinamide induced type 2 diabetes mellitus. Int. J. Pharm. Pharm. Sci., 5(2): 382-387.
  • Saravanan, G., Ponmurugan, P. 2011. Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats. Chemico-Biological Interact., 189: 100-106.
  • Scheff, SW., Ansari, MA., Roberts, KN. 2013. Neuroprotective effect of Pycnogenol® following traumatic brain injury. Experiment. Neurol., 239: 183–191.
  • Torel, J., Cillard, J., Cillard, P. 1986. Antioxidant activity of fl avonoids and reactivity with peroxy radical. Phytochemistry, 25(2): 383–385.
  • Tsin, ATC., Griffi n, BW., Mata, NL., Yu, HS., Williams, GW., Crider, JY., Chandler, ML. 1993. Vitamin A homeostasis in the diabetic rat. J. Clin. Biochem. Nutr., 15: 23-31.
  • Tuzlacı, E., Erol, MK. 1999. Turkish folk medicinal plants. Part II: Eğridir (Isparta). Fitoterapia, 70: 593-610.
  • Wang, XT., Li, J., Liu, L., Hu, N., Jin, S., Liu, C., Mei, D., Liu, XD. 2012. Tissue cholesterol content alterations in streptozotocin-induced diabetic rats. Acta Pharmacol. Sin., 33: 909-917.
  • Wolffenbuttel, BHR., Graal, M.B. 1996. New treatments for patients with type 2 diabetes mellitus. Postgrad. Med. J., 72: 657-662.
  • Yesil-Celiktas, O., Ganzera, M., Akgun, İ., Sevimli, C., Korkmaz, KS., Bedir, E. 2009. Determination of polyphenolic constituents and biological activities of bark extracts from different Pinus species. J. Sci. Food Agric., 89: 1339-1345.
  • Chemico-Biol. Interact., 186: 219-227.
Karaelmas Fen ve Mühendislik Dergisi-Cover
  • ISSN: 2146-4987
  • Yayın Aralığı: Yılda 2 Sayı
  • Başlangıç: 2011
  • Yayıncı: ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ
Arşiv
Sayıdaki Diğer Makaleler

Karabük Atmosferinin Spor Analizi

Ayse KAPLAN, Yasin ÖZDOĞAN

Some alternative sweeteners xylitol, sorbitol, sucralose and stevia : Review

Basmaa S SHEET, Nevzat ARTIK, Mahmoud A AYED, Omar Fawzi ABDULAZİZ

Johrenia Dichotoma DC. Apiaceae Üzerinde Görüntü Analiz Sistemi İle Karyolojik Bir Çalışma

Esra MARTIN, Yavuz BAGCI, Muhittin DİNC, Fahim ALTİNORDU, Ahmet DURAN

Akyaka Beldesi Gökova Körfezi, Muğla Sahil Sedimanlarının Bazı Jeolojik Özellikleri

Hülya Keskin ÇITIROĞLU, Ayten CESUR, Gürkan BACAK, İbrahim ONUR

Streptozotosinin Neden Olduğu Tip-1 Diyabette Çam Yağının Karaciğer ve Böbrek Dokusundaki Bazı Biyokimyasal Parametrelere Etkisi

Ersin DEMİR